187989-19-1

Upstream product

• 187989-17-9 2-(4-benzyloxyphenyl)-2-(N,N-diethylamino)acetonitrile 
• 824-94-2 p-methoxybenzyl chloride 
• 3669-46-3 1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone 
• 100-44-7 benzyl chloride 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 104-01-8 4-Methoxyphenylacetic acid 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 

Downstream Products

• 1202376-37-1 5-(4-(benzyloxy)phenyl)-4-(4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one 
• 1271728-04-1 C₁₆H₁₃NO₃ 
• 1202376-38-2 5-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one 
• 1202369-73-0 4-(4-methoxyphenyl)-2,2-dimethyl-5-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 

Relevant academic research and scientific papers

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.

1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS

1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.

Pyridine compounds, intermediates compositions and methods of use

The present invention is directed to compounds of Formula I: STR1 wherein: n is 2 or 3; R is dimethylamino, diethylamino, 1-piperidinyl, 1-pyrrolidinyl, 4-morpholinyl, or 1-hexamethyleneimino; R1 is hydrogen, loweralkyl of C1 -C