187992-65-0Relevant academic research and scientific papers
Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: Orally active prostacyclin mimetics. Part 6
Tanaka, Akira,Hattori, Kouji,Taniguchi, Kiyoshi,Okitsu, Osamu,Tabuchi, Seiichiro,Nishio, Mie,Nagakura, Yasunori,Maeda, Noriaki,Murai, Hidetsugu,Seki, Jiro
, p. 4861 - 4864 (2007/10/03)
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-prost
4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors
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Example 30, (2010/02/05)
Heterocyclic compounds of the formula: ???whereinR1 is carboxy or esterified carboxy,R2 is phenyl or (C1-C6)alkylphenyl,R3 is phenyl or (C1-C6)alkylphenyl,R4 is hydrog
4,5-diaryl oxazole derivatives
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, (2008/06/13)
This invention relates to new heterocyclic compounds, compositions, process of making and method of use thereof for inhibition of platelet aggregation, vasodilation, antihypertensive activity and prostaglandin I2 agonist.
