18800-75-4 Usage
Description
Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)is a complex organic compound with a unique molecular structure. It is characterized by its white crystalline powder form and is an intermediate for Mifamurtide (M343940), a drug used in the treatment of osteosarcoma.
Uses
Used in Pharmaceutical Industry:
Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)is used as an intermediate for the synthesis of Mifamurtide, a drug that is employed in the treatment of osteosarcoma. Mifamurtide increases the survival rate of nonmetastatic and metastatic patients undergoing chemotherapy for osteosarcoma, making it a crucial component in the development of this life-saving medication.
Chemical Properties:
Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)is a white crystalline powder, which indicates its solid state and appearance. The specific chemical properties of this compound, such as solubility, reactivity, and stability, would depend on its molecular structure and the functional groups present in the molecule.
Check Digit Verification of cas no
The CAS Registry Mumber 18800-75-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,0 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18800-75:
(7*1)+(6*8)+(5*8)+(4*0)+(3*0)+(2*7)+(1*5)=114
114 % 10 = 4
So 18800-75-4 is a valid CAS Registry Number.
18800-75-4Relevant articles and documents
Phosphotyrosine-containing dipeptides as high-affinity ligands for the p56(lck) SH2 domain
Llinàs-Brunet, Montse,Beaulieu, Pierre L.,Cameron, Dale R.,Ferland, Jean-Marie,Gauthier, Jean,Ghiro, Elise,Gillard, James,Gorys, Vida,Poirier, Martin,Rancourt, Jean,Wernic, Dominik,Betageri, Raj,Cardozo, Mario,Jakes, Scott,Lukas, Suzanne,Patel, Usha,Proudfoot, John,Moss, Neil
, p. 722 - 729 (2007/10/03)
Src homology-2 (SH2) domains are noncatalytic motifs containing approximately 100 amino acid residues that are involved in intracellular signal transduction. The phosphotyrosine-containing tetrapeptide Ac-pYEEI binds to the SH2 domain of p56(lck) (Lck) with an affinity of 0.1 μM. Starting from Ac-pYEEI, we have designed potent antagonists of the Lck SH2 domain which are reduced in peptidic character and in which the three carboxyl groups have been eliminated. The two C-terminal amino acids (EI) have been replaced by benzylamine derivatives and the pY + 1 glutamic acid has been substituted with leucine. The best C-terminal fragment identified, (S)-1-(4-isopropylphenyl)ethylamine, binds to the Lck SH2 domain better than the C-terminal dipeptide EI. Molecular modeling suggests that the substituents at the 4-position of the phenyl ring occupy the pY + 3 lipophilic pocket in the SH2 domain originally occupied by the isoleucine side chain. This new series of phosphotyrosine-containing dipeptides binds to the Lck SH2 domain with potencies comparable to that of tetrapeptide 1.