188054-45-7

Basic information

• Product Name: 4-acridinecarboxylic acid methyl ester
• Synonyms: 4-acridinecarboxylic acid methyl ester
• CAS NO: 188054-45-7
• Molecular Weight: 237.258
• Mol File: 188054-45-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 413.6±18.0 °C(Predicted)
• Density: 1.256±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-acridinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acridinecarboxylic acid methyl ester(188054-45-7)
• EPA Substance Registry System: 4-acridinecarboxylic acid methyl ester(188054-45-7)

Safety Data

• Hazardous Substances Data: 188054-45-7(Hazardous Substances Data)

Usage

General Description

4-acridinecarboxylic acid methyl ester, also known as acridine-4-carboxylic acid methyl ester, is a chemical compound that belongs to the acridine family. It is a derivative of acridine with a methyl ester group attached to the carboxylic acid moiety. 4-acridinecarboxylic acid methyl ester is used in organic synthesis and medicinal chemistry as a building block for the preparation of various acridine-based compounds with potential biological activities. It has been studied for its antitumor, antimicrobial, and antiviral properties. Additionally, it has been investigated as a fluorescent probe for DNA and RNA visualization and as a photosensitizer in photodynamic therapy. Overall, 4-acridinecarboxylic acid methyl ester is a versatile chemical with potential applications in various fields of science.

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 188054-37-7 N-(2-Hydroxymethylphenyl)anthranilsaeuremethylester 
• 100038-81-1 methyl 2-benzoate 
• 188054-38-8 N-(2-Formylphenyl)anthranilsaeuremethylester 

Downstream Products

• 31327-97-6 acridine-4-carboxylic acid 
• 89459-25-6 N-[2-(dimethylamino)ethyl]acridine-4-carboxamide 

Relevant articles and documents

Preparation method of multi-functional group acridine compound and derivative thereof

The present invention relates to a preparation method of a multi-functional group acridine compound and a derivative thereof. According to the present invention, specifically a bisphosphine ligand and palladium complex catalyzed series connection coupling/cyclization reaction is used to prepare the acridine compound represented by a formula I, wherein various groups are defined in the specification; and the method has advantages of mild reaction condition, simple operation and wide substrate applicability, and the multi-functional group acridine compound and the derivative thereof can be prepared in the high yield manner. The formula I is defined in the specification.

Process for the preparation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

PCT No. PCT/GB97/02884 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17649 PCT Pub. Date Apr. 30, 1998A process for producing an acridine carboxamide of formula (I): wherein each of R1, R2, R5 and R6,

Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl] acridine- 4-carboxamide

The mixed topoisomerase I/II inhibitor N-[2- (dimethylamino)ethyl]acridine-4-carboxamide (DACA) is currently in clinical trial as an anticancer drug. A series of acridine-substituted analogues were prepared, using a new synthetic route to substituted acri