188054-38-8

Basic information

• Product Name: N-(2-Formylphenyl)anthranilsaeuremethylester
• Synonyms: N-(2-Formylphenyl)anthranilsaeuremethylester
• CAS NO: 188054-38-8
• Molecular Weight: 255.273
• Mol File: 188054-38-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-Formylphenyl)anthranilsaeuremethylester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Formylphenyl)anthranilsaeuremethylester(188054-38-8)
• EPA Substance Registry System: N-(2-Formylphenyl)anthranilsaeuremethylester(188054-38-8)

Safety Data

• Hazardous Substances Data: 188054-38-8(Hazardous Substances Data)

Upstream product

• 247223-75-2 2-(2-(2-Methoxycarbonylphenyl)aminophenyl)-1,3-dioxolan 
• 100038-81-1 methyl 2-benzoate 
• 134-20-3 2-carbomethoxyaniline 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 188054-37-7 N-(2-Hydroxymethylphenyl)anthranilsaeuremethylester 

Downstream Products

• 188054-45-7 4-acridinecarboxylic acid methyl ester 
• 188054-37-7 N-(2-Hydroxymethylphenyl)anthranilsaeuremethylester 
• 31327-97-6 acridine-4-carboxylic acid 
• 247223-85-4 N-(2-(β-(N'-Benzyloxycarbonyl)aminoethyl)phenyl)anthranilsaeuremethylester 
• 247223-86-5 N-(2-(β-(N'-Benzyloxycarbonyl)aminoethyl)phenyl)anthranilsaeure 
• 247223-83-2 N-(2-(β-Aminoethyl)phenyl)anthranilsaeuremethylester 
• 247223-87-6 N-(2-(β-ammonioethyl)phenyl)anthranilat 
• 247223-81-0 N-(2-Cyanomethylphenyl)anthranilsaeuremethylester 
• 247223-79-6 N-(2-Chlormethylphenyl)anthranilsaeuremethylester 
• 89459-25-6 N-[2-(dimethylamino)ethyl]acridine-4-carboxamide 

Relevant articles and documents

Process for the preparation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

PCT No. PCT/GB97/02884 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17649 PCT Pub. Date Apr. 30, 1998A process for producing an acridine carboxamide of formula (I): wherein each of R1, R2, R5 and R6,

A new synthesis of substituted acridine-4-carboxylic acids and the anticancer drug N-[2-dimethylamino)ethyl]acridine-4-carboxamide (DACA)

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-carboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehyde 7, and cyclisation of these with trifluoroacetic acid to the methyl acridine-4-carboxylates (8), followed by base hydrolysis. Direct amidation of 8a provides a new route to the clinical anticancer drug DACA (3) which avoids use of the irritant acid 2a.