188057-20-7

Basic information

• Product Name: 4-IODO-PYRIDIN-3-OL
• Synonyms: 4-IODO-PYRIDIN-3-OL;4-IODO-3-HYDROXYPYRIDINE;AKOS A0602-0922;2-Iodo-3-hydroxypyridine;2-Iodo-3-pyridinol;3-Hydroxy-4-iodopyridine
• CAS NO: 188057-20-7
• Molecular Formula: C₅H₄INO
• Molecular Weight: 220.99583
• Product Categories: Heterocycle-Pyridine series
• Mol File: 188057-20-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 196-200℃
• Boiling Point: 296.603 °C at 760 mmHg
• Flash Point: 133.181 °C
• Appearance: /
• Density: 2.142 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-IODO-PYRIDIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-PYRIDIN-3-OL(188057-20-7)
• EPA Substance Registry System: 4-IODO-PYRIDIN-3-OL(188057-20-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 188057-20-7(Hazardous Substances Data)

Usage

General Description

4-IODO-PYRIDIN-3-OL is an organic chemical compound with the molecular formula C5H4INOH. It is a derivative of pyridine and contains an iodine atom and a hydroxyl group attached to the third carbon atom of the pyridine ring. 4-IODO-PYRIDIN-3-OL is used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It can also be utilized as a building block in organic chemistry reactions and as a reagent in chemical research. 4-IODO-PYRIDIN-3-OL is available commercially and is handled and used in accordance with standard laboratory safety practices.

InChI:InChI=1/C5H4INO/c6-4-1-2-7-3-5(4)8/h1-3,8H

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 51581-40-9 3-pyridyl diethylcarbamate 
• 81245-25-2 3-(methoxymethoxy)pyridine 
• 98976-94-4 N,N-diethyl-4-iodo-3-pyridyl O-carbamate 
• 81245-27-4 4-iodo-3-(methoxymethoxy)pyridine 

Downstream Products

• 750638-97-2 2,4-diiodo-pyridin-3-ol 
• 289473-52-5 N-phenoxycarbonyl-6-{2-[(3-(trifluoromethylsulfonyl)oxy)-4-pyridinyl]-ethyl}-1,2,3,4-tetrahydropyridine 
• 289473-50-3 N-phenoxycarbonyl-6-{2-[(3-acetoxy)-4-pyridinyl]ethyl}-1,2,3,4-tetrahydropyridine 
• 289473-49-0 N-phenoxycarbonyl-6-{2-[(3-acetoxy)-4-pyridinyl]ethynyl}-1,2,3,4-tetrahydropyridine 
• 289473-51-4 N-phenoxycarbonyl-6-{2-[(3-hydroxy)-4-pyridinyl]ethyl}-1,2,3,4-tetrahydropyridine 
• 289473-53-6 C₁₉H₂₀N₂O₂ 
• 154057-83-7 4-(4-bromo-phenylsulfanyl)-pyridine 

Relevant articles and documents

MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS

The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and/or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, C. difficile associated diarrhea, traveller's diarrhea, diarrhea induced by graph versus host disease, other types of diarrhea, dyspepsia, irritable bowel syndrome, chemotherapy-induced nausea and vomiting (emesis) and post-operative nausea and vomiting and functional gastrointestinal disorders. In addition, the compounds possess utility for the treatment of diseases and disorders characterized by poor stomach or intestinal absorption, such as short bowel syndrome, celiac disease and cachexia. The compounds also have use for the treatment of inflammatory diseases and disorders of the gastrointestinal tract, such as inflammatory bowel disease, ulcerative colitis, Crohn's disease and pancreatitis. Accordingly, methods of treating such disorders and pharmaceutical compositions including compounds of the present invention are also provided.

New approaches to bicylic vinyl heterocycles from propargylic acetals

(Chemical Equation Presented) The paper describes further studies on the intramolecular carbolithiation of propargylic acetals with aryllithiums leading to 2-vinylbenzofurans and 3-vinylfuropyridines. Attempts to extend the cascade to [4.4.0] binuclear he

Synthesis of two conformationally constrained analogues of the minor tobacco alkaloid anabasine.

The anabasine analogues spiro[4-azaindan-1,2'-piperidine] (7) and spiro[6-azaindan-1,2'-piperidine] (8) have been prepared. A series of palladium-catalyzed reactions, where an intramolecular cyclization constituted a key reaction, were utilized for the pr