18818-40-1

Basic information

• Product Name: 2-(3-methylphenyl)quinazolin-4-ol
• Synonyms: 2-(3-methylphenyl)quinazolin-4-ol
• CAS NO: 18818-40-1
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.26858
• Mol File: 18818-40-1.mol
• Article Data: 62

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-methylphenyl)quinazolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylphenyl)quinazolin-4-ol(18818-40-1)
• EPA Substance Registry System: 2-(3-methylphenyl)quinazolin-4-ol(18818-40-1)

Safety Data

• Hazardous Substances Data: 18818-40-1(Hazardous Substances Data)

Usage

Compound class

Quinazoline

Core structure

Quinazoline

Hydroxy group position

4-position

Methylphenyl group position

2-position

Potential pharmacological properties

Antiviral, antineoplastic, and antihypertensive

Possible applications

Pharmaceutical drug development

Additional research needed

Chemical and biological properties understanding

Upstream product

• 153172-70-4 N-(2-cyanophenyl)-3-methylbenzamide 
• 75541-73-0 N-m-toluoyl-anthranilic acid methyl ester 
• 61560-94-9 3-methylphenyloxoacetic acid 
• 28144-70-9 anthranilic acid amide 
• 620-23-5 m-tolyl aldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 610-15-1 2-nitrobenzamide 
• 587-03-1 3-methylbenzyl alcohol 
• 100-80-1 3-methylstyrene 
• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 100-81-2 3-methyl-benzenemethanamine 
• 625-95-6 3-Iodotoluene 
• 144-62-7 oxalic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1229610-01-8 2-(3-methylphenyl)-4-phenyl-quinazoline 
• 1448311-28-1 C₂₂H₁₈N₂O₃S 

Relevant articles and documents

N^N^O hydrazone capped pincer type palladium complex catalysed construction of quinazolinones from alcohols

New Pincer type Pd(II) complex [Pd(NNO)(PPh3)] (1) prompted synthesis of quinazolinones via dehydrogenative coupling of readily accessible alcohols, and o-aminobenzamide is described. A diverse range of quinazolinones has been synthesized efficiently with good to excellent yields employing low catalyst loading (0.5 mol%) under the aerobic condition without any additives/oxidants. A plausible mechanism for the construction of quinazolinones has been proposed via cyclic aminal intermediate. Large-scale synthesis attests to the productiveness of the current strategy.

Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones

In the present work, we have developed a novel and environmentally friendly method for the synthesis of quinazolinones using fluorescein as a photocatalyst via a condensation reaction of o-aminobenzamides and aldehydes under visible light irradiation. In this protocol, neither toxic oxidants nor transition-metal catalysts were needed, and a series of quinazolinones could be obtained in high efficiencies. In addition, this reaction can be extended to gram levels and has a large potential of wide application in future industrialization.