18818-49-0

Basic information

• Product Name: 5-METHYL-2-(3-METHYLPHENYL)-1H-BENZIMIDAZOLE
• Synonyms: 5-METHYL-2-(3-METHYLPHENYL)-1H-BENZIMIDAZOLE;5-Methyl-2-(3-Methylphenyl)benziMidazole, 95%;5-Methyl-2-m-tolyl-1H-benzoimidazole
• CAS NO: 18818-49-0
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.29
• Mol File: 18818-49-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-2-(3-METHYLPHENYL)-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-(3-METHYLPHENYL)-1H-BENZIMIDAZOLE(18818-49-0)
• EPA Substance Registry System: 5-METHYL-2-(3-METHYLPHENYL)-1H-BENZIMIDAZOLE(18818-49-0)

Safety Data

• Hazardous Substances Data: 18818-49-0(Hazardous Substances Data)

Upstream product

• 496-72-0 4-methyl-1,2-diaminobenzene 
• 620-23-5 m-tolyl aldehyde 
• 587-03-1 3-methylbenzyl alcohol 
• 583-68-6 2-bromo-p-toluidine 
• 20680-59-5 3-methylbenzenecarboximidamide hydrochloride 
• 29289-13-2 2-iodo-4-methylaniline 
• 1224442-24-3 3-methyl-N-(5-methyl-2-nitrophenyl)benzene carboximidamide 

Relevant articles and documents

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de-polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidat

Tunable Triazole-Phosphine-Copper Catalysts for the Synthesis of 2-Aryl-1H-benzo[d]imidazoles from Benzyl Alcohols and Diamines by Acceptorless Dehydrogenation and Borrowing Hydrogen Reactions

Triazole-phosphine-copper complexes (TAP?Cu) have been synthesized and applied as tunable and efficient catalysts for the selective synthesis of fluoro-substituted 2-aryl-1H-benzo[d]imidazole and 1-benzyl-2-aryl-1H-benzo[d]imidazole derivatives from simple alcohols in only one step. TAP?Cu exhibited excellent and tunable catalytic activity for both dehydrogenation and borrowing hydrogen reactions with more than 80 examples being demonstrated for the first time. It was observed that the ligand played a critical role in catalyst activity. Mechanistic studies and deuterium labeling experiments indicated that the reactions proceeded by an initial and reversible alcohol dehydrogenation resulting in a copper hydride intermediate. This was also supported by the direct observation of a diagnostic copper hydride signal by solid-state infrared spectroscopy. The TAP?Cu-H complex showed absorptions at 912 cm?1 that could be assigned to copper?hydride stretches. Furthermore, the direct trapping of an intermediate bisimine was also successfully performed. (Figure presented.).

Catalyst/ligand-free synthesis of benzimidazoles and quinazolinones from amidines via intramolecular transamination reaction

An efficient catalyst/ligand-free synthesis of benzimidazoles and quinazolinones from amidines in quantitative yields has been described.