1882-86-6

Upstream product

• 122314-93-6 (8R,9R,10S,13R,14R,16S,17R)-17-Acetyl-16-methoxy-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione 
• 104621-27-4 (3aR,7aS,8S,9R,10aS,10bS,10cS)-9-(tert-Butyl-dimethyl-silanyloxy)-8-isopropenyl-3a,6,7a-trimethyl-1,2,3a,5,7,7a,8,9,10,10a,10b,10c-dodecahydro-4H-cyclopenta[a]phenalen-3-one 
• 104621-22-9 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetaldehyde 
• 104621-28-5 (2R,3S,3aS,5aR,6R,9aS,9bS)-3-Acetyl-2-(tert-butyl-dimethyl-silanyloxy)-3a,6-dimethyl-6-(3-oxo-butyl)-decahydro-cyclopenta[a]naphthalene-5,7-dione 
• 104621-27-4 (7aS,8S,9R,10aS)-9-(tert-Butyl-dimethyl-silanyloxy)-8-isopropenyl-3a,6,7a-trimethyl-1,2,3a,5,7,7a,8,9,10,10a,10b,10c-dodecahydro-4H-cyclopenta[a]phenalen-3-one 
• 104621-23-0 (2S,3R,3aR,7aS)-2-Hydroxy-3-isopropenyl-3a-methyl-octahydro-inden-5-one 
• 122314-90-3 5-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1,6-diisopropenyl-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-4-yl]-2-methyl-pent-1-en-3-one 
• 122314-89-0 5-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-1,6-diisopropenyl-7a-methyl-octahydro-inden-4-yl]-2-methyl-pent-1-en-3-one 
• 122314-84-5 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid isopropyl ester 
• 104621-26-3 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid 
• 104621-25-2 3-((1S,2R,3aS,4R,7aS)-2-Hydroxy-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl)-propionic acid isopropyl ester 
• 122314-82-3 (1R,2S,3aS,7aR)-1-Isopropenyl-7a-methyl-2,6-bis-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-indene 
• 104621-24-1 (2S,3R,3aR,7aR)-3-Isopropenyl-3a-methyl-2-trimethylsilanyloxy-1,2,3,3a,4,7a-hexahydro-inden-5-one 
• 67-56-1 methanol 

Downstream Products

• 382-45-6 (+/-)-adrenosterone 
• 53-06-5 (+/-)-Cortisone 
• 53-06-5 (+/-)-cortisone 
• 382-45-6 (+/-)-adrenosterone 

Relevant academic research and scientific papers

New steroid 11-ketone group oxidation synthesizing process

The invention discloses a new steroid 11-ketone group oxidation synthesizing process. The method comprises that in a nonprotic organic solvent, under conditions of dimethyl sulfoxide (DMSO) as an oxidant, an organic alkali, dichlorophenyl phosphate and a piperidine aminoxyl free radical, a steroid 11-alpha hydroxyl compound is subjected to an oxidation reaction to generate a steroid 11-ketone group compound, the reaction temperature is -10 DEG C to a solvent reflux temperature, and the piperidine aminoxyl free radical is selected from the group consisting of a 2,2,6,6-tetramethylpiperidine-1-oxyl free radical or an analogue thereof.

Total Synthesis of ( +/-)-Cortisone. Double-Hydroxylation Reaction for Corticoid Synthesis

Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.