1882-86-6

Basic information

• Product Name: pregna-4,16-diene-3,11,20-trione
• Synonyms: Pregna-4,16-diene-3,11,20-trione
• CAS NO: 1882-86-6
• Molecular Formula: C₂₁H₂₆O₃
• Molecular Weight: 326.4293
• Mol File: 1882-86-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 504.4°C at 760 mmHg
• Flash Point: 217.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 2.66E-10mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: pregna-4,16-diene-3,11,20-trione(CAS DataBase Reference)
• NIST Chemistry Reference: pregna-4,16-diene-3,11,20-trione(1882-86-6)
• EPA Substance Registry System: pregna-4,16-diene-3,11,20-trione(1882-86-6)

Safety Data

• Hazardous Substances Data: 1882-86-6(Hazardous Substances Data)

Upstream product

• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 123267-87-8 21-acetoxy-16α,17-epoxy-pregn-4-ene-3,11,20-trione 
• 104621-28-5 (2R,3S,3aS,5aR,6R,9aS,9bS)-3-Acetyl-2-(tert-butyl-dimethyl-silanyloxy)-3a,6-dimethyl-6-(3-oxo-butyl)-decahydro-cyclopenta[a]naphthalene-5,7-dione 
• 104621-27-4 (3aR,7aS,8S,9R,10aS,10bS,10cS)-9-(tert-Butyl-dimethyl-silanyloxy)-8-isopropenyl-3a,6,7a-trimethyl-1,2,3a,5,7,7a,8,9,10,10a,10b,10c-dodecahydro-4H-cyclopenta[a]phenalen-3-one 
• 104621-21-8 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetic acid tert-butyl ester 
• 104621-23-0 (2S,3R,3aR,7aS)-2-Hydroxy-3-isopropenyl-3a-methyl-octahydro-inden-5-one 
• 122314-84-5 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid isopropyl ester 
• 104621-26-3 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid 
• 104621-25-2 3-((1S,2R,3aS,4R,7aS)-2-Hydroxy-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl)-propionic acid isopropyl ester 
• 104621-24-1 (2S,3R,3aR,7aR)-3-Isopropenyl-3a-methyl-2-trimethylsilanyloxy-1,2,3,3a,4,7a-hexahydro-inden-5-one 
• 104621-22-9 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetaldehyde 
• 104621-27-4 (7aS,8S,9R,10aS)-9-(tert-Butyl-dimethyl-silanyloxy)-8-isopropenyl-3a,6,7a-trimethyl-1,2,3a,5,7,7a,8,9,10,10a,10b,10c-dodecahydro-4H-cyclopenta[a]phenalen-3-one 

Downstream Products

• 53-06-5 (+/-)-Cortisone 
• 382-45-6 (+/-)-adrenosterone 
• 53-06-5 (+/-)-cortisone 
• 382-45-6 (+/-)-adrenosterone 

Relevant articles and documents

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Total Synthesis of ( +/-)-Cortisone. Double-Hydroxylation Reaction for Corticoid Synthesis

Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.