188252-72-4

Upstream product

• 67-56-1 methanol 
• 3592-25-4 1,5-dichloropentan-3-one 
• 62-53-3 aniline 
• 149-73-5 trimethyl orthoformate 
• 19125-34-9 1-phenylpiperidin-4-one 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 117896-69-2 1-phenyl-4-hydroxypiperidine 

Downstream Products

• 19125-34-9 1-phenylpiperidin-4-one 
• 105123-93-1 2'-O-(4-Methoxy-1-phenylpiperidin-4-yl)uridine 
• 186644-66-6 4-Methoxy-1-phenyl-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.

Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones

When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,