188255-06-3Relevant academic research and scientific papers
A convergent synthesis of an LTD4 antagonist, RG12525
Sledeski, Adam W.,O'Brien, Michael K.,Truesdale, Larry K.
, p. 1129 - 1132 (2007/10/03)
An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.
