19820-77-0Relevant articles and documents
Development of one-pot benzylic amination reactions of azine N-oxides
Liman, Menek?e,Türkmen, Yunus Emre
supporting information, p. 1723 - 1727 (2018/04/02)
An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield.
Metal-free C(sp3)-H bond sulfonyloxylation of 2-alkylpyridines and alkylnitrones
Wang, Chang-Sheng,Dixneuf, Pierre H.,Soulé, Jean-Fran?ois
supporting information, p. 4954 - 4957 (2018/07/25)
Pyridin-2-ylmethyl tosylate derivatives are obtained in high yields from 2-alkylpyridine 1-oxides via a [3,3]-sigmatropic rearrangement of the adduct between 2-alkylpridine 1-oxides with benzenesulfonyl chlorides. Moreover, alkylnitrones also undergo [3,3]-sigmatropic rearrangement to give α-tosylated ketones after hydrolysis. Substitution reactions with nucleophiles then lead to diverse useful functionalizations for the synthesis of pincer ligands.
A convergent synthesis of an LTD4 antagonist, RG12525
Sledeski, Adam W.,O'Brien, Michael K.,Truesdale, Larry K.
, p. 1129 - 1132 (2007/10/03)
An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.
