19820-77-0

Basic information

• Product Name: QUINOLIN-2-YLMETHYL 4-METHYLBENZENESULFONATE
• Synonyms: 2-Quinolinemethanol,4-methylbenzenesulfonate (ester) (9CI); 2-Quinolinemethanol, p-toluenesulfonate(ester) (8CI)
• CAS NO: 19820-77-0
• Molecular Formula: C₁₇H₁₅NO₃S
• Molecular Weight: 313.37
• Mol File: 19820-77-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 493.6°C at 760 mmHg
• Flash Point: 252.3°C
• Appearance: /
• Density: 1.295g/cm³
• Vapor Pressure: 2.1E-09mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: QUINOLIN-2-YLMETHYL 4-METHYLBENZENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOLIN-2-YLMETHYL 4-METHYLBENZENESULFONATE(19820-77-0)
• EPA Substance Registry System: QUINOLIN-2-YLMETHYL 4-METHYLBENZENESULFONATE(19820-77-0)

Safety Data

• Hazardous Substances Data: 19820-77-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H15NO3S/c1-13-6-10-16(11-7-13)22(19,20)21-12-15-9-8-14-4-2-3-5-17(14)18-15/h2-11H,12H2,1H3

Upstream product

• 1076-28-4 2-methylquinoline N-oxide 
• 98-59-9 p-toluenesulfonyl chloride 
• 91-63-4 2-methylquinoline 

Downstream Products

• 188255-05-2 2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline 
• 188255-07-4 2-(4-{2-[1-(Tetrahydro-pyran-2-yl)-1H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline 
• 188255-06-3 2-(4-{2-[2-(Tetrahydro-pyran-2-yl)-2H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline 
• 120128-20-3 2-[[4-[[2-(1H-tetrazol-5-ylmethyl)phenyl]methoxy]phenoxy]methyl]quinoline 

Relevant articles and documents

Development of one-pot benzylic amination reactions of azine N-oxides

An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield.

A convergent synthesis of an LTD4 antagonist, RG12525

An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.