188343-76-2

Upstream product

• 816464-47-8 benzyl 4-(2-bromoacetyl)piperidine-1-carboxylate 
• 160809-34-7 4-acetyl-piperidine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 85475-10-1 4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 108-89-4 picoline 
• 188345-15-5 4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione 

Downstream Products

• 188343-78-4 2-(4-fluorophenyl)-5-(piperidin-4-yl)-3-(pyridin-4-yl)-pyrrole 
• 1426406-57-6 N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide 
• 1426406-59-8 N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide 
• 339988-84-0 2-(4-fluorophenyl)-5-(N-ethylpiperidin-4-yl)-3-(pyridin-4-yl)pyrrole 
• 188343-77-3 4-(2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl)pyridine 

Relevant academic research and scientific papers

THERAPEUTIC METHODS AND COMPOUNDS

The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.

Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites

Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infect

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in vivo activities. The most potent

Aliphatic hydroxy substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Diaryl piperidyl pyrrole derivatives as antiprotozoal agents

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

2-substituted aryl pyrroles, compositions containing such compounds and methods of use

The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity o