85475-10-1Relevant articles and documents
Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites
Towle, Tyrell,Chang, Isabel,Kerns, Robert J.,Bhanot, Purnima
, p. 1874 - 1877 (2013/04/10)
Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infect
Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent Melanin-Concentrating Hormone Receptor 1 (MCH-R1) antagonists
Berglund, Susanne,Egner, Bryan J.,Graden, Henrik,Graden, Joakim,Morgan, David G.A.,Inghardt, Tord,Giordanetto, Fabrizio
scheme or table, p. 4859 - 4863 (2009/05/27)
A series of 1,3-disubstituted-1H-pyrrole-based antagonists of the human Melanin-Concentrating Hormone Receptor 1 (h-MCH-R1) are reported. High-throughput screening of the AstraZeneca compound collection yielded 1, a hit with moderate affinity towards MCH-