188352-12-7Relevant academic research and scientific papers
Potent, orally absorbed glucagon receptor antagonists
De Laszlo, Stephen E.,Hacker, Candice,Li, Bing,Kim, Dooseop,MacCoss, Malcolm,Mantlo, Nathan,Pivnichny, James V.,Colwell, Larry,Koch, Gregory E.,Cascieri, Margaret A.,Hagmann, William K.
, p. 641 - 646 (2007/10/03)
The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5- bromo-2-propyloxyphenyl)pyrrole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.
Pyrroles and other heterocycles as inhibitors of P38 kinase
De Laszlo, Stephen E.,Visco, Denise,Agarwal, Lily,Chang, Linda,Chin, Jayne,Croft, Gist,Forsyth, Amy,Fletcher, Daniel,Frantz, Betsy,Hacker, Candice,Hanlon, William,Harper, Coral,Kostura, Matthew,Li, Bing,Luell, Sylvie,MacCoss, Malcolm,Mantlo, Nathan,O'Neill, Edward A.,Orevillo, Chad,Pang, Margaret,Parsons, Janey,Rolando, Anna,Sahly, Yousif,Sidler, Kelley,Widmer, W. Rick,O'Keefe, Stephen J.
, p. 2689 - 2694 (2007/10/03)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl- 2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L- 167307)) reduces secondary paw swe
