443797-07-7Relevant academic research and scientific papers
Potent, orally absorbed glucagon receptor antagonists
De Laszlo, Stephen E.,Hacker, Candice,Li, Bing,Kim, Dooseop,MacCoss, Malcolm,Mantlo, Nathan,Pivnichny, James V.,Colwell, Larry,Koch, Gregory E.,Cascieri, Margaret A.,Hagmann, William K.
, p. 641 - 646 (2007/10/03)
The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5- bromo-2-propyloxyphenyl)pyrrole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.
