188352-45-6

Upstream product

• 188352-12-7 4-[2-(4-Fluoro-phenyl)-5-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-pyridine 
• 443797-07-7 2-(4-fluoro-phenyl)-4-(4-methylsulfanyl-phenyl)-1-pyridin-4-yl-butane-1,4-dione 
• 126443-15-0 (E)-3-(4-fluorophenyl)-1-(4-(methylthio)phenyl)prop-2-en-1-one 
• 1778-09-2 4-(Methylthio)acetophenone 

Relevant academic research and scientific papers

Potent, orally absorbed glucagon receptor antagonists

The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5- bromo-2-propyloxyphenyl)pyrrole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.

2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use

The present invention addresses 2, 5-substituted aryl pyrroles of the formula: STR1 or a pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine