188400-51-3

Basic information

• Product Name: 1-[2-(3-Fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine
• Synonyms: L-775606
• CAS NO: 188400-51-3
• Molecular Formula: C₂₅H₂₉FN₆
• Molecular Weight: 432.54848
• Mol File: 188400-51-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-[2-(3-Fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(3-Fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine(188400-51-3)
• EPA Substance Registry System: 1-[2-(3-Fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine(188400-51-3)

Safety Data

• Hazardous Substances Data: 188400-51-3(Hazardous Substances Data)

Upstream product

• 197244-83-0 4-(4-[1,3]Dioxolan-2-yl-butyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 118336-86-0 5-chloro-n-valeraldehyde ethylene acetal 
• 456-48-4 3-Fluorobenzaldehyde 
• 174609-57-5 5-[4-(tert-Butyloxycarbonyl)piperazin-1-yl]pentanal dimethyl acetal 
• 78643-42-2 5-bromopentanal dimethyl acetal 
• 179421-16-0 4-(4-iodo-phenyl)-4H-[1,2,4]triazole 
• 188400-93-3 1-[2-(3-fluorophenyl)ethyl]piperazine 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 540-37-4 p-aminoiodobenzene 
• 25017-13-4 1-(2-bromoethyl)-3-fluorobenzene 
• 52059-53-7 2-(3-fluorophenyl)ethanol 
• 862158-61-0 4-[2-(3-fluoro-phenyl)-ethyl]piperazine-1-carboxylic acid ethyl ester 
• 862158-41-6 N-(4-[1,2,4]-triazol-4-yl-phenyl)-hydrazinecarboxylic acud tert-butyl ester 
• 862158-39-2 1-but-3-enyl-4-[2-(3-fluoro-phenyl)-ethyl]piperazine 

Relevant articles and documents

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

3-(piperazinylpropyl)indoles: Selective, orally bioavailable h5-HT(1D) receptor agonists as potential antimigraine agents

Clinically effective antimigraine drugs such as Sumatriptan have similar affinity at h5-HT(1D) and h5-HT(1B) receptors. In the search for a h5- HT(1D)-selective agonist as an antimigraine agent, a novel series of 3- (propylpiperazinyl)indoles have been sy

Selective, orally active 5-HT(1D) receptor agonists as potential antimigraine agents

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