18841-73-1

Usage

Uses

Used in Pharmaceutical Industry:
(17beta)-9,17-dihydroxyandrost-4-en-3-one is used as an intermediate in the biosynthesis of androgens and estrogens for the development of pharmaceutical products targeting hormonal imbalances and related health conditions.
Used in Biochemical Research:
(17beta)-9,17-dihydroxyandrost-4-en-3-one is used as a substrate in biochemical studies and research focused on hormonal regulation and metabolism, aiding in the understanding of endocrine system functions and the development of treatments for related disorders.

Upstream product

• 57-88-5 cholesterol 
• 58-22-0 testosterone 

Relevant academic research and scientific papers

Steroid 9α-hydroxylation during testosterone degradation by resting Rhodococcus equi cells

The conversion pathway of testosterone to androst-4-ene-3,17-dione and 9α-hydroxy androstane metabolites, 9α-hydroxyandrost-4-ene-3,17- dione and 9α,17β-dihydroxyandrost-4-en-3-one was proposed for the ring degradation in steroids by a minimal liquid medium (NMMP)-dispersed Rhodococcus equi ATCC 14887. The microorganism produced 9α-hydroxy androstane metabolites from testosterone at high conversion ratio without the addition of ring degradation inhibitory agents. Several NMMP-based media showed the similar effect on the microbial transformation, in which the respective molar yields of 9α-hydroxyandrost-4-ene-3,17-dione and 9α,17β-dihydroxyandrost-4-en-3-one were approx. 3 to 47% and approx. 3 to 11%, respectively, whereas nutrient broth, a rich medium, basically showed no accumulation. On the basis of this evidence, magnesium sulfate and casamino acids among the components of NMMP were found to compromise the determinant for the production of the 9α-hydroxy androstane metabolites without appreciable decomposition of the steroid ring system.

MICROBIAL DEGRADATION OF THE PHYTOSTEROL SIDE-CHAIN TO 24-OXO PRODUCTS

A mutant of the potent sterol degrader Mycobacterium fortuitum (ATCC 6842) has been isolated which is defective in its ability to degrade both the steroid nucleus and sterol side-chains that are branched at the 24-position.Bioconversions of phytosterol mixtures by this mutant resulted in the accumulation of the novel 24-oxo intermediates 9-hydroxy-27-nor-4-cholestene-3,24-dione (II) and 9-hydroxy-26,27-dinor-4-cholestene-3,24-dione (III).Under the same conditions, cholesterol is degraded mainly to 9-hydroxy-4-androstene-3,17-dione (I) by this organism.