188478-67-3

Upstream product

• 219547-55-4 [5-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-6-(4-methoxymethoxy-phenyl)-1-(2-methylsulfanyl-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester 
• 165809-38-1 2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester 
• 26190-68-1 1-chloromethyl-2-methylsulfanylbenzene 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 124-63-0 methanesulfonyl chloride 
• 219547-56-5 ethyl 5-aminomethyl-6-(4-methoxymethoxyphenyl)-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 188479-15-4 ethyl 2,4(1H,3H)-dioxo-5-bromomethyl-l-(2-methylthiobenzyl)-6-(4-methoxymethoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate 
• 165808-27-5 ethyl 6-(4-acetoxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 165808-20-8 ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate 
• 165808-07-1 ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 165807-46-5 ethyl 6-(4-methoxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 165807-52-3 ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 

Downstream Products

• 188478-81-1 2,4(1H,3H)-dioxo-6-(4-methoxymethoxyphenyl)-1-(2-methylthiobenzyl)-5-(methanesulfonamidomethyl)-thieno[2,3-d]pyrimidine-3-acetic acid 
• 219547-70-3 ethyl 6-(4-methoxymethoxyphenyl)-5-(N-methyl-N-methylsulfonylaminomethyl)-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 

Relevant academic research and scientific papers

Thieno[2,3-d]pyrimidine-3-acetic acids a new class of nonpeptide endothelin receptor antagonists

On the basis of structural information for the cyclic hexapeptide endothelin (ET) receptor antagonist, TAK-044, a series of thieno[2,3- d]pyrimidine-2,4-dione derivatives bearing a carboxyl group and aromatic rings that were important for receptor binding