188540-74-1Relevant articles and documents
Hydroxyacids as efficient chiral spacers for asymmetric intramolecular [2+2] photocycloadditions
Faure, Sophie,Piva-Le Blanc, Sylvie,Piva, Olivier,Pete, Jean-Pierre
, p. 1045 - 1048 (1997)
An indirect and efficient enantioselective [2+2] photocycloaddition between 3-carboxycyclohex-2-enone and allyl alcohol, involving a three step sequence, is described. When the reagents are linked by covalent bonds to a chiral spacer such as L-lactic or (R)-3-hydroxybutyric acids, the corresponding photocycloadducts are isolated in high yields, with very high regio and diastereoselectivities. The reaction affords polyfunctional cyclobutanes as pure enantiomers.
