188554-17-8

Basic information

• Product Name: 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine
• Synonyms: 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine
• CAS NO: 188554-17-8
• Molecular Weight: 547.868
• Mol File: 188554-17-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine(188554-17-8)
• EPA Substance Registry System: 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine(188554-17-8)

Safety Data

• Hazardous Substances Data: 188554-17-8(Hazardous Substances Data)

Upstream product

• 873071-82-0 4-ethynyl-2-[(1E)-2-methylbut-1-en-3-yn-1-yl]pyridine 
• 813-19-4 bis(tri-n-butyltin) 
• 138846-06-7 2-[(1’E,3’E)-3’-methyl-4’-iodobuta-1’,3’-dien-1’yl]-1,3,3-trimethylcyclohex-1-ene 
• 260353-34-2 4-ethoxycarbonyl-2-[3-tert-butyldimethylsiloxy-2-methyl-(1E)-propenyl]pyridine 
• 260353-35-3 2-[3-tert-butyldimethylsiloxy-2-methyl-(1E)-propenyl]-4-hydroxymethylpyridine 
• 344907-82-0 (E)-3-(4-Hydroxymethyl-pyridin-2-yl)-2-methyl-propenol 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 
• 62285-98-7 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide 
• 188554-16-7 4-formyl-2-[3-oxo-2-methyl-(1E)-propenyl]pyridine 
• 188554-14-5 Trifluoro-methanesulfonic acid 4-formyl-pyridin-2-yl ester 
• 188554-15-6 2-(2-Methyl-propenyl)-pyridine-4-carbaldehyde 
• 188554-13-4 2-hydroxypyridine-4-carboxaldehyde 

Relevant articles and documents

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.