188554-13-4Relevant articles and documents
Total synthesis of the ocular age pigment A2-E: A convergent pathway
Ren,Sakai,Nakanishi
, p. 3619 - 3620 (1997)
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INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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Page 132, (2008/06/13)
The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).
Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration
Ben-Shabat, Shimon,Parish, Craig A.,Hashimoto, Masaru,Liu, Jianghua,Nakanishi, Koji,Sparrow, Janet R.
, p. 1533 - 1540 (2007/10/03)
The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.