188554-13-4

Basic information

• Product Name: 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
• Synonyms: 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE;2-HYDROXY-4-FORMYLPYRIDINE;2-HYDROXY-PYRIDINE-4-CARBALDEHYDE;2-HYDROXYPYRIDINE-4-CARBOXALDEHYDE;4-Pyridinecarboxaldehyde,1,2-dihydro-2-oxo-(9CI);2-AMINO-5-(AMINOMETHYL)-4-METHYLTHIAZOLE;2-Hydroxyisonicotinaldehyde;2-Oxo-1,2-dihydro-pyridine-4-carbaldehyde
• CAS NO: 188554-13-4
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• Product Categories: PYRIDINE;pharmacetical;API intermediates;Pyridines;Heterocycle-Pyridine series
• Mol File: 188554-13-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 79-81 °C
• Boiling Point: 333.7 °C at 760 mmHg
• Flash Point: 175.1 °C
• Appearance: /
• Density: 1.365 g/cm³
• Vapor Pressure: 0.000341mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.17±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE(188554-13-4)
• EPA Substance Registry System: 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE(188554-13-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 188554-13-4(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-4-pyridinecarboxaldehyde is a chemical compound with the molecular formula C6H5NO2. It is also known as 4-Pyridinecarboxaldehyde, 2-hydroxy- and is a light yellow to brown powder. The chemical is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. It may also be used in the production of dyes and pigments. Additionally, 2-Hydroxy-4-pyridinecarboxaldehyde is utilized as an intermediate in the manufacturing of other organic compounds. While it has several applications, the chemical should be handled with caution and proper safety measures should be implemented during its use and storage.

InChI:InChI=1/C5H9N3S/c1-3-4(2-6)9-5(7)8-3/h2,6H2,1H3,(H2,7,8)

Upstream product

• 13466-41-6 4-methyl-1H-pyridin-2-one 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 

Downstream Products

• 188554-17-8 2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine 
• 864757-89-1 4-[(E)-2-(4-fluorophenyl)vinyl]pyridin-2-ol 
• 959960-94-2 C₁₈H₁₄BrNO₂ 
• 959960-93-1 C₁₂H₁₀BrNO₂ 
• 85684-61-3 3-(difluoromethoxy)-benzaldehyde 
• 1268516-11-5 (2-(difluoromethoxy)pyridin-4-yl)methanol 
• 1226710-09-3 C₂₅H₂₆ClFN₄O₂ 
• 959960-92-0 C₁₂H₈BrNO₂ 
• 672317-71-4 C₁₈H₁₄BrN₅O 

Relevant articles and documents

Total synthesis of the ocular age pigment A2-E: A convergent pathway

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INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.