188562-99-4

Upstream product

• 188562-97-2 methyl 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-enecarboxylate 
• 100-46-9 benzylamine 
• 208928-20-5 methyl 2-methoxy-4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carboxylate 
• 422506-83-0 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-iodocyclohex-1-ene 
• 188562-91-6 tert-butyl N-benzyl(4-oxocyclohexyl)carbamate 

Downstream Products

• 188563-01-1 4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-cyclohex-1-enecarboxylic acid methyl ester 
• 422506-97-6 methyl 4-{N-benzyl-[2-(phenylselanyl)-2-oxoethyl]amino}cyclohex-1-enecarboxylate 
• 422506-89-6 methyl 4-[N-benzyl-N-(tert-butoxycarbonylmethyl)amino]cyclohex-1-enecarboxylate 
• 188563-10-2 4-[Benzyl-(2-chloro-acetyl)-amino]-cyclohex-1-enecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of 4-aminocyclohex-1-enecarboxylates from Danishefsky's diene

An efficient BF3·Et2O mediated conversion of Diels-Alder adduct 1 of Danishefsky's diene and methyl acrylate yielded cyclohexenones 2 and 3. Subsequent reductive amination with several amines using NaBH(OAc)3 in acetic acid medium gave 4-alkylaminocyclohex-1-enecarboxylate derivatives (4a-e) in a concise form.

Decarbonylative radical cyclization of α-amino selenoesters upon electrophilic alkenes. A general method for the 6-azabicyclo[3.2.1]octane synthesis

α-Amino selenoester-tethered electronically poor alkenes on treatment with tributyltin hydride or TTMSS undergo intramolecular radical cyclization to provide 6-azabicyclo[3.2.1]octanes through 1-aminomethyl radical intermediates.