188562-91-6

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 100-46-9 benzylamine 
• 131511-13-2 4-(N-benzylamino)cyclohexanone ethylene acetal 
• 24424-99-5 di-tert-butyl dicarbonate 
• 142009-99-2 4-(benzylamino)cyclohexane-1-one 

Downstream Products

• 188562-93-8 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-en-yl trifluoromethanesulfonate 
• 422506-83-0 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-iodocyclohex-1-ene 
• 422507-07-1 trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol 
• 187807-23-4 N-benzyl-N-(3-cyclohexenyl)amine 
• 188562-97-2 methyl 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-enecarboxylate 
• 188562-99-4 methyl 4-benzylaminocyclohex-1-ene-1-carboxylate 
• 422507-12-8 4-[N-benzyl-N-(methoxycarbonylmethyl)amino]-1-cyclohexene 
• 187807-24-5 4-{benzyl-[2-(methylselanyl)-2-oxoethyl]amino}cyclohex-1-ene 
• 422507-09-3 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene 
• 422506-89-6 methyl 4-[N-benzyl-N-(tert-butoxycarbonylmethyl)amino]cyclohex-1-enecarboxylate 
• 422506-97-6 methyl 4-{N-benzyl-[2-(phenylselanyl)-2-oxoethyl]amino}cyclohex-1-enecarboxylate 
• 422507-48-0 [N-benzyl-N-(4-cyano-3-cyclohexenyl)amino]phosphonic dichloride 
• 187807-19-8 4-(benzylamino)cyclohex-1-encarbonitrile 
• 1610517-29-7 ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate 

Relevant academic research and scientific papers

3-(dimethylaminomethyl) cyclohex-4-alcohol derivative as well as preparation method and pharmaceutical application thereof

The invention belongs to the field of pharmacy, and relates to a 3-(dimethylaminomethyl) cyclohex-4-alcohol derivative with a general formula (I) or a salt thereof and a preparation method, and relates to an application of the compound in treatment of opioid receptor mediated diseases. The present invention provides a pharmaceutically acceptable solvate or hydrate of a compound of formula (I), and also provides a pharmaceutical composition comprising: a compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof; and a pharmaceutically acceptable carrier. The medicine prepared from the compound can be used for treating or improving diseases related to an opioid receptor; wherein the diseases can be selected from but not limited to pain, gastrointestinal diseases and depression.

Synthesis of a series of polar, orthogonally protected, α,α-disubstituted amino acids

The synthesis of four novel, 'cationic', α,α-disubstituted amino acids is described. The new amino acids use an orthogonal protection scheme making them suitable for incorporation via solid-phase peptide synthesis.

Synthesis of 2-azabicyclo[3.3.1]lnonanes by means of (carbamoyl)dichloromethyl radical cyclization

A new procedure for the synthesis of 2-azabicyclo[3.3.1]nonanes by intramolecular carboradical cyclization of 4-(trichloroacetamido)cyclohexenes substituted with an electron withdrawing substituent tester or nitrile) is described. The procedure allows the preparation of synthetically interesting azabicyclos 14 and 15 in nearly 70% yield.