18860-95-2

Usage

Uses

Used in Organic Synthesis:
(2E)-1,4-dibromo-2-methylbut-2-ene is used as an intermediate in the synthesis of various organic compounds and materials, playing a crucial role in the creation of new chemical entities with diverse applications.
Used in Organic Chemistry Reactions:
In the realm of organic chemistry, (2E)-1,4-dibromo-2-methylbut-2-ene is employed as a reagent, particularly for the formation of carbon-carbon bonds, which are fundamental in constructing complex organic molecules.
Used in Pharmaceutical Industry:
(2E)-1,4-dibromo-2-methylbut-2-ene is utilized in the pharmaceutical industry for the development of new drugs, contributing to the advancement of medicinal chemistry and the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
(2E)-1,4-dibromo-2-methylbut-2-ene also finds application in the agrochemical industry, where it is used in the synthesis of pesticides and other agrochemical products, helping to improve crop protection and yield.
Safety Consideration:
Given its potentially harmful nature, (2E)-1,4-dibromo-2-methylbut-2-ene should be handled with care, adhering to proper safety protocols to minimize risks to human health and the environment.

Upstream product

• 64251-93-0 3,4-dibromo-2-methyl-but-1-ene 
• 78-79-5 isoprene 
• 616-02-4 citraconic acid anhydride 

Downstream Products

• 19857-58-0 1,4-dibromo-2-methyl-butane-2,3-diol 
• 5944-58-1 ethyl 2-methyl-5-isopropenyl-4,5-dihydrofuran-3-carboxylate 
• 109176-08-1 ethyl 2,5-dimethyl-5-vinyl-4,5-dihydrofuran-3-carboxylate 
• 80485-95-6 2-methyl-3-acetyl-5-isopropenyl-4,5-dihydrofuran 
• 80485-94-5 1-(2,5-dimethyl-5-vinyl-4,5-dihydrofuran-3-yl)ethan-1-one 
• 61111-66-8 dimethyl 2-vinyl-2-methyl-1,1-cyclopropanedicarboxylate 
• 61111-65-7 <2RS>-2-Isopropenylcyclopropan-1,1-dicarbonsaeure-dimethylester 
• 79-08-3 bromoacetic acid 
• 598-31-2 1-bromoacetone 
• 39198-72-6 5-Methyl-3-methylsulfanyl-cyclohex-4-ene-1,1,2,2-tetracarbonitrile 
• 1110784-72-9 C₉H₁₇Br 
• 1117736-37-4 3-(bromomethyl)-2-methylhept-1-ene 
• 1110784-71-8 (R)-3-(bromomethyl)-2-methylhept-1-ene 

Relevant academic research and scientific papers

Formal [5+1] annulation reactions of dielectrophilic peroxides: Facile access to functionalized dihydropyrans

A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.

PRENYL BIBENZYLS FROM THE LIVERWORTS RADULA PERROTTETII AND RADULA COMPLANATA

A new dihydrobenzofuran and a new chromene derivatives have been isolated from the liverwort Radula perrottetii, together with the known 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl, 2(R)-2-isopropenyl-6,7-dihydroxy-4-(2-phenylethyl)dihydrobenzofuran, 2,2-dimethyl-7-hydroxy-5-(2-phenylethyl)chromene, 3,5-dihydroxy-6-carbomethoxy-2-(3-methyl-2-butenyl)bibenzyl, three bis(bibenzyls) and perrottetins E, F and G.The structures of the new compounds have been characterized as 2(R)-2-isopropenyl-6-hydroxy-4-(2-phenylethyl)dihydrobenzofuran and 2,2-dimethyl-7,8-dihydroxy-5-(2-phenylethyl)chromene by 1H and 13C NMR spectral analysis and synthesis.The structures of the previously reported chalcone and three prenyl bibenzyls, perrottetins A, B and C, and the other two bibenzyls, isolated from R. perrottetii are revised by analysis of their 1H and 13C NMR data, difference NOE experiments and synthesis of their derivatives.Radulanin L, a new bibenzyl with a dihydrooxepin skeleton was isolated from R. complanata together with 2- and 4-(3-methyl-2-butenyl)-3,5-dihydroxybibenzyls and its structure elucidated by comparison of 1H and 13C NMR spectral data with those of radulanins A and H.The structures of the previously reported radulanins A and H isolated from R. complanata are confirmed as correct by difference NOE.Some prenyl-containing bibenzyls showed 5-lipoxygenase and calmodulin inhibitory activity and vasopressin antagonist activity.R. perrottetii is a chemically isolated species in the Radulaceae.

PREPARATIVE SYNTHESIS OF ISOPRENE OXIDE

The reaction of isoprene, hydrogen peroxide, and commercial hydrobromic acid gives 1-bromo-2-methyl-3-buten-2-ol, the low-temperature dehydrobromination of which gives isoprene oxide in high yield.