188630-50-4Relevant academic research and scientific papers
Structure-activity relationship of indoloquinoline analogs anti-MRSA
Zhao, Min,Kamada, Tomonori,Takeuchi, Aya,Nishioka, Hiromi,Kuroda, Teruo,Takeuchi, Yasuo
, p. 5551 - 5554 (2015/11/17)
Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.
Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines
Takeuchi, Yasuo,Oda, Toshiaki,Chang, Ming-Rong,Okamoto, Yoko,Ono, Junko,Oda, Yoko,Harada, Kyoko,Hashigaki, Kuniko,Yamato, Masatoshi
, p. 406 - 411 (2007/10/03)
Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
