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UDP-N-acetylmuramic acid α-anomer is a key chemical compound involved in the biosynthesis of bacterial cell walls. It is an α-anomer of UDP-N-acetylmuramic acid, which is a nucleotide sugar that plays a crucial role in the formation of peptidoglycan, a major component of the bacterial cell wall. UDP-N-acetylmuramic acid α-anomer is formed through the enzymatic reaction of UDP-N-acetylglucosamine and L-alanine, catalyzed by the enzyme MurA. The α-anomer form is particularly important as it is the active form that participates in the subsequent steps of peptidoglycan synthesis, ultimately contributing to the structural integrity and shape of bacterial cells.

18867-75-9

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18867-75-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 18867-75-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,6 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18867-75:
(7*1)+(6*8)+(5*8)+(4*6)+(3*7)+(2*7)+(1*5)=159
159 % 10 = 9
So 18867-75-9 is a valid CAS Registry Number.

18867-75-9Relevant academic research and scientific papers

Multi gram synthesis of UDP-N-acetylmuramic acid

Dini,Drochon,Ferrari,Aszodi

, p. 143 - 145 (2000)

As part of an effort to discover novel antibacterial agents, a new and efficient synthesis was established in order to provide a large amount of UDP-N-acetylmuramic acid (UDP-MurNAc).

Optimization of UDP-N-acetylmuramic acid synthesis

Humljan, Jan,Starcevic,Car,Stefanic Anderluh,Kocjan,Jenko,Urleb

, p. 102 - 106 (2008/09/21)

UDP-N-acetylmuramic acid (UDP-MurNAc) is a substrate of MurC, an important enzyme in the intracellular pathway of bacterial peptidoglycan biosynthesis. Various approaches towards preparation of UDP-Mur/VAc have been published but these synthetic preparations were shown to include many problematic steps. An optimization study with the focus on muramyl phosphate and UMP-morpholidate coupling was performed, resulting in a synthetic procedure enabling robust and easily reproducible production on a multi-gram scale.

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