188677-48-7

Basic information

• Product Name: 4-Pyridinecarboxamide, 3-chloro-N-phenyl-
• CAS NO: 188677-48-7
• Molecular Formula: C12H9ClN2O
• Molecular Weight: 232.669
• Mol File: 188677-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Pyridinecarboxamide, 3-chloro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxamide, 3-chloro-N-phenyl-(188677-48-7)
• EPA Substance Registry System: 4-Pyridinecarboxamide, 3-chloro-N-phenyl-(188677-48-7)

Safety Data

• Hazardous Substances Data: 188677-48-7(Hazardous Substances Data)

Upstream product

• 3034-31-9 N-phenylisonicotinamide 

Downstream Products

• 98273-79-1 3-chloropyridine-4-carboxylic acid methyl ester 
• 88912-27-0 3-chloro-isonicotinic acid 

Relevant articles and documents

Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metallation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids

The synthesis of the halogenated picolin- and isonicotinalides (3) and (4) via metallation (n-BuLi) of the anilides (1) and (2) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of (3) and (4), as a way of regiospecific transformation of picoline and isonicotine acids into their C3-halogenated derivatives, is described.