188679-30-3

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 5067-90-3 2-chlorobenzoyl isothiocyanate 
• 124-40-3 dimethyl amine 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 188679-31-4 ethyl 4-(2-chlorophenyl)-2-dimethylamino-5-thiazolecarboxylate 

Relevant academic research and scientific papers

Normal coordinate analysis and crystal structure of N,N-dimethyl-N′-(2-chloro-benzoyl)thiourea

In the present paper, the crystal structural and vibrational analysis of the N,N-dimethyl-N′-(2-chloro-benzoyl)thiourea molecule is reported. The molecular structure of the title compound was determined by single crystal X-ray diffraction method. The compound crystallizes monoclinic, space group P21/c with a = 5.6601(13) A, b = 10.748(2) A, c = 17.778(4) A, β = 94.266(5)°, and V = 1078.5(4) A3 with Z = 4 for dcalc = 1.495 g/cm3. Calculations of the vibrational frequencies have been carried out on the basis of normal coordinate analysis using simple general valence force field in Wilson's GF matrix method with the SPSIM computer program. With the help of this modern technique we were able to complete the assignment of the vibrational spectrum of the title compound.

Synthesis, characterization and antimicrobial activities of some metal complexes with N′-(2-chloro-benzoyl)thiourea ligands: The crystal structure of fac- [CoL3] and cis-[PdL2]

We report the synthesis, structural characterization and antimicrobial activities of N,N-dimethyl-N′-(2-chloro-benzoyl)thiourea (L1H) and N-pyrrolidine-N′-(2-chlorobenzoyl)thiourea (L2H) and their Ni(II), Cu(II), Zn(II), Pt(II), Pd(II) and Co(III) complexes. The structure of the prepared compounds was investigated by using elemental analyses, IR, 1H-NMR, UV-Vis, mass spectra and magnetic susceptibility. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. All compounds showed antimicrobial activity, however, the antibacterial efficacy is better than antifungal activity. Molecular structures of Co(L1)3 and Pd(L1)2 were determined by single crystal X-ray diffraction methods. The ligands coordinate to Ni(II), Cu(II), Zn(II), Pt(II) and Pd(II) in a bidentate manner yielding essentially neutral complexes of the type ML2. The coordination polyhedra around the Co(III) ion are distorted octahedra.

Azole-phenyl urea derivatives as ACAT inhibitors and their production

The present invention relates to azole-phenyl urea derivatives represented by the general formula (I): [wherein each of R1, R2and R3is H, halogen, C1-8alkyl or the like, and A is a group represented by the formula (i) or (ii): (wherein R4, R5, R6and X are as defined in the specification.)] and a pharmacologically acceptable salt thereof, which have ACAT-inhibitory activity and are useful as a prophylactic and therapeutic agent for hypercholesterolemia, atherosclerosis and various diseases caused by them; a process for producing said derivative; and an ACAT inhibitor containing said derivative or salt as an active ingredient.