18869-47-1

Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as a key building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs with diverse therapeutic applications.
Used in Antioxidant Applications:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as an antioxidant agent for its potential to protect cells from oxidative stress and damage. Its antioxidant properties may contribute to the prevention of various diseases and conditions associated with oxidative stress, such as neurodegenerative disorders and cancer.
Used in Anti-inflammatory Applications:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate pain. Its anti-inflammatory effects may be beneficial in the treatment of various inflammatory conditions, such as arthritis and other autoimmune diseases.
Used in Analgesic Applications:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as an analgesic agent for its potential to relieve pain. Its analgesic properties may be useful in the management of chronic pain and other painful conditions.
Used in Neurological Disorder Treatment:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as a potential therapeutic agent for the treatment of neurological disorders. Its potential neuroprotective effects may contribute to the prevention or treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
Used in Cancer Treatment:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as a potential therapeutic agent for cancer treatment. Its potential anti-cancer properties may contribute to the inhibition of tumor growth and the enhancement of the effectiveness of conventional cancer therapies.
Used in Research and Industrial Applications:
METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used in research and industrial applications for the development of new pharmaceuticals and bioactive compounds. Its availability from chemical suppliers makes it accessible for use in various research and development projects.

Upstream product

• 67-56-1 methanol 
• 60-18-4 L-tyrosine 
• 3417-91-2 tyrosine methyl ester hydrochloride 
• 7647-01-0 hydrogenchloride 
• 556-02-5 ?Tyr 
• 77714-35-3 3-(4-Hydroxy-phenyl)-2-((E)-2-methyl-3-oxo-propenylamino)-propionic acid methyl ester 
• 77714-34-2 3-(4-Hydroxy-phenyl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester 

Downstream Products

• 97529-43-6 3-(4-Hydroxy-phenyl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester 
• 89236-84-0 2-[(E)-2-(Diphenyl-phosphinoyl)-vinylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-48-1 2-[2-(5-Chloro-1H-indol-3-yl)-2-oxo-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 3410-66-0 D-tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 78807-85-9 2-(2-Acetylamino-4-phenyl-thiazole-5-sulfonylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-53-8 2-[2-(5-Bromo-1H-indol-3-yl)-2-oxo-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-59-4 3-(4-Hydroxy-phenyl)-2-[2-(5-nitro-1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester 
• 59824-46-3 tyrosine 
• 67-56-1 methanol 
• 556-02-5 ?Tyr 
• 321371-23-7 3-(4-hydroxy-phenyl)-2-[(4-isopropyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester 
• 1080-06-4 L-Tyr-OMe 
• 50563-23-0 methyl-[2-hydroxyimino-3-(4-hydroxyphenyl)]propionate 

Relevant academic research and scientific papers

Method for synthesizing tyrosine framework type periodic mesoporous organosilicas materials

The invention relates to a method for preparing tyrosine framework type periodic mesoporous organosilicas materials. The method for synthesizing the tyrosine framework type periodic mesoporous organosilicas materials includes esterifying tyrosine in methanol by the aid of thionyl chloride; carrying out acrylation on the tyrosine by the aid of hydrazine hydrate and carrying out reaction on the tyrosine and isocyanic acid propyltriethoxysilane to obtain tyrosine organosilicas precursors; hydrolyzing the tyrosine organosilicas precursors and surfactants under acidic conditions to form PMO (periodic mesoporous organosilicas) materials; removing the surfactants from the PMO materials by means of extraction to ultimately form PMO materials with specific morphological structures. The tyrosine is used as a substrate. The methanol is used as a solvent. The method has the advantages synthesis reaction raw materials are simple and are easily available, synthesis operation is simple and convenient and is easy to implement, and the method is high in yield and low in energy consumption and is safe and inexpensive; the tyrosine framework type periodic mesoporous organosilicas materials prepared by the aid of the method have important application prospects in the fields of biosensors, catalyst carriers, adsorbents, sustained-release medicine capsules, chromatographic separation and the like.

BISAMIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR REDUCING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN

This invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are allosteric effectors that reduce the oxygen-binding affinity of hemoglobin, which can enhance the efficacy of radiation therapy for cancer and which are useful for the treatment of ischemia and other conditions.

BISAMIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR REDUCING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN

This invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are allosteric effectors that reduce the oxygen-binding affinity of hemoglobin, which can enhance the efficacy of radiation therapy for cancer and which are useful for the treatment of ischemia and other conditions.

Palladium-catalyzed oxalyl amide assisted direct ortho-alkynylation of arylalkylamine derivatives at δ and ε positions

Palladium-catalyzed oxalyl amide directed ortho-alkynylation of arylalkylamine derivatives is reported for the first time. A wide variety of β-arylethamine and γ-arylpropamine derivatives are compatible with this protocol. This method provides a general means to synthesize substituted alkynylarylalkylamine derivatives, highlighting the ability of oxalyl amide in promoting C-H functionalization at unique δ and ε positions.

Synthesis of d,l-amino acid derivatives bearing a thiol at the β-position and their enzymatic optical resolution

Amino acids bearing a thiol group at the β-position are useful for native chemical ligation. Phenylalanine and tyrosine derivatives bearing a thiol group at the β-position were synthesized. Racemic phenylalanine and tyrosine were selected as starting materials and were introduced a bromo atom at the β-position by photoreaction. Subsequent substitution reaction of the bromo atom with p-methoxybenzylmercaptan yielded the corresponding amino acids bearing a thiol group at the β-position. Enzymatic optical resolution using l-aminoacylase and subsequent chemical conversion gave the corresponding optically pure l- and d-phenylalanine and tyrosine derivatives bearing a thiol group at the β-position.

A small molecule peptidomimetic of spider silk and webs

A peptidomimetic compound containing leucine, tyrosine and malonic acid self-assembles through various noncovalent interactions to form spider silk-like fibers at ambient temperature. From the high-density liquid, a liquid-solid phase transition is initiated at 20 °C and solidification occurs upon contact with air. The fiber has comprehensive mechanical strength and optical properties similar to spider silk, and can be used to mimic a natural spider web. This journal is

Oxidation of oximes to nitrile oxides with hypervalent iodine reagents

Iodobenzene diacetate in MeOH containing a catalytic amount of TFA efficiently oxidizes aldoximes to nitrile oxides. The latter may be trapped in situ with olefins in a bimolecular or an intramolecular mode. The new method enables the execution of tandem oxidative dearomatization of phenols/intramolecular nitrile oxide cycloaddition sequences leading to useful synthetic intermediates.

Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase

A series of inhibitors of the aspartate transcarbamoylase, an enzyme involved in pyrimidine nucleotide biosynthesis, has been synthesized. These inhibitors are analogues of a highly potent inhibitor of this enzyme, N-phosphonacetyl-l-aspartate (PALA). Analogues have been synthesized with modifications at the α- and β-carboxylates as well as at the aspartate moiety. The ability of these compounds to inhibit the enzyme was evaluated. These studies, with functional group modified PALA derivatives, showed that amide groups can be a useful substitute of the carboxylate in order to reduce the charge on the molecule, and indicate that the relative position of the functional group in the β-position is more critical than the nature of the functional group. Some of the molecules synthesized here are potent inhibitors of the enzyme.

INTERMEDIATE COMPOUND WHICH IS USED FOR THE PREPARATION OF PIOGLITAZONE

The present invention relates to a novel compound of formula (IV) which is an intermediate that can be used for the preparation of pioglitazone. It also relates to a method of obtaining the novel compound (IV) starting from the natural product L-tyrosine, in which the amino group is protected in the form of aromatic imino group, and a method of obtaining pioglitazone from the said intermediate.

EXOGENOUS MARKERS FOR OXIDATIVE STRESS

The invention provides oxogenous markers, designed and synthesized for the measurement and characterization of oxidative/nitrosative stress levels, thus enable the identification of the type of reactive ROS/NRS involved, characterization of the damaged products and their formation kinetics, and thereby the identification of pathological conditions associated with oxidative/nitrosative stress, before appearing or at the stage of development.