188782-68-5Relevant articles and documents
Thienopyridine bis-heterocyclic compound preparation technology
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Paragraph 0007; 0019-0020, (2018/03/01)
The invention provides a thienopyridine bis-heterocyclic compound preparation technology which comprises the following steps: 1) putting acetophenone and thiophene-2-formaldehyde in an alcohol solventto react under the alkali action to obtain a compound II; 2) putting the compound II and 2-cyanoethyl thioacetamide in the alcohol solvent to react under the organic alkali action to obtain a compound III; 3) putting the compound III and bromoacetophenone in the alcohol solvent to react under the strong base action to obtain a compound I. A reaction route is shown in the specification. The preparation technology disclosed by the invention has the following advantages that the raw materials and reagents utilized by the reaction are all general synthesized reagents and has cheap price and easiness in obtaining; all the steps have moderate reaction conditions and simple aftertreatment operation; the reaction yield is higher, and the product purity is high; the whole preparation technology has the advantages of convenience in operation, low product cost and ability in meeting an industrial production requirement.
Reactions of styrylthienyl ketone, styryl furyl ketone with thiocyanoacetamide: Synthesis of several new pyridines, thieno[2,3-b]pyridines, pyrido [2′,3′:4,5]thieno[3,2-c]pyridazines and pyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidin one derivatives
Attaby, Fawzy A.
, p. 1 - 12 (2007/10/03)
Styryl thienyl ketone and Styryl furyl ketone 2a,b reacted with thiocyanoacetamide(1) to give the dihydropyridinethiones 3a,b which used as starting material for the synthesis of several heterocyclic compounds. Reaction with several halogeno-esters, halogeno-ketones and chloroacetamide gave 2-S-alkoyl pyridines 5a-d, 10a-d, 13a,b and 19a,b thieno[2,3-c] pyridines 6a,b, 11a,b 14a,b and 20a-d, pyrido[2′,3′,4:5]thieno[2,3-c]pyridazines 8a,b and pyrido[2′.3′:-4,5]thieno[2,3-d]pyrimidinones 15a, b 16a,b and 17a,b. Structures were established based on elemental analyses and spectral data studies.