188818-73-7

Basic information

• Product Name: Cyclohexanecarboxylic acid, 2-amino-, 1,1-dimethylethyl ester, (1S-trans)-
• Synonyms: Cyclohexanecarboxylic acid, 2-amino-, 1,1-dimethylethyl ester, (1S-trans)-;Cyclohexanecarboxylic acid, 2-aMino-, 1,1-diMethylethyl ester, (1S-2S)-
• CAS NO: 188818-73-7
• Molecular Formula: C11H21NO2
• Molecular Weight: 199.28994
• Product Categories: AMINOACID
• Mol File: 188818-73-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexanecarboxylic acid, 2-amino-, 1,1-dimethylethyl ester, (1S-trans)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 2-amino-, 1,1-dimethylethyl ester, (1S-trans)-(188818-73-7)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 2-amino-, 1,1-dimethylethyl ester, (1S-trans)-(188818-73-7)

Safety Data

• Hazardous Substances Data: 188818-73-7(Hazardous Substances Data)

Upstream product

• 22173-21-3 tert-butyl cyclohex-1-ene-1-carboxylate 
• 151294-67-6 (1S,2R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-cyclohexanecarboxylic acid tert-butyl ester 

Relevant articles and documents

ISOQUINOLINES AS UROKINASE INHIBITORS

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First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S)-2-[2′-(N-hydroxycarbamoylmethyl)-3′- phenylpropionylamino]cyclohexane-1-carboxylic acid

The first asymmetric synthesis of Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S)-2-[2′-(N-hydroxycarbamoylmethyl)-3′- phenylpropionylamino]cyclohexane-1-carboxylic acid is achieved using lithium amide (R)-5 and pyrrolidinone auxiliary (R)-6; the pyrrolidinone auxiliary is used to create (2S)-benzylsuccinic acid derivative (S)-4 while lithium amide (R)-5 is used to synthesize tert-butyl (1S,2R)-2-aminocyclohexanecarboxylate 3.