188820-26-0

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-amino-4-(4-chlorophenyl)-1,4-dihydro-6-phenyl-, ethyl ester
• CAS NO: 188820-26-0
• Molecular Formula: C19H18ClN3O2
• Molecular Weight: 355.824
• Mol File: 188820-26-0.mol

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-amino-4-(4-chlorophenyl)-1,4-dihydro-6-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-amino-4-(4-chlorophenyl)-1,4-dihydro-6-phenyl-, ethyl ester(188820-26-0)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-amino-4-(4-chlorophenyl)-1,4-dihydro-6-phenyl-, ethyl ester(188820-26-0)

Safety Data

• Hazardous Substances Data: 188820-26-0(Hazardous Substances Data)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 25354-83-0 (Z)-ethyl 2-benzoyl-3-(4'-chlorophenyl)-3-propenoate 

Relevant articles and documents

Microwave-mediated regioselective synthesis of novel pyrimido[1,2-a]pyrimidines under solvent-free conditions

Ethyl 2-amino-4-aryl-1,4-dihydro-6-phenylpyrimidine-5-carboxylates readily react, under microwave irradiation and solvent-free conditions, with 3-formylchromone or diethyl (ethoxymethylene)malonate to yield novel pyrimido[1,2-a]pyrimidines. The structure of the final products, deduced from the spectral data and confirmed by X-ray analysis, allows us to suggest reaction pathways.

Synthesis of Ethyl 2-Aminodihydro-5-pyrimidinecarboxylate Derivatives and 3,7-Diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[1,2-a]pyrimidines

Reactions of ethyl 3-aryl-2-benZoylpropenoateS 1 with guanidine and N-alkyl(or benzyl)guanidines have been investigated. Ethyl 2-aminodihydro-5-pyrimidinecarboxylate derivatives 3, 4 or 5 and 3,7-diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[