188847-00-9

Basic information

• Product Name: 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate
• Synonyms: 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate;Methyl 1-Cbz-pyrrolidine-3-carboxylate;Methyl 1-Cbz-3-pyrrolidinecarboxylate;Methyl 1-Cbz-pyrrolidine-...
• CAS NO: 188847-00-9
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.28908
• Mol File: 188847-00-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate(188847-00-9)
• EPA Substance Registry System: 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate(188847-00-9)

Safety Data

• Hazardous Substances Data: 188847-00-9(Hazardous Substances Data)

Usage

General Description

"1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate" is a chemical compound that belongs to the class of pyrrolidine carboxylates. It is a derivative of pyrrolidine and has a benzyl and a methyl group attached to the nitrogen atom of the pyrrolidine ring. 1-benzyl 3-methyl pyrrolidine-1,3-dicarboxylate is often used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals. Additionally, it has shown potential in research for its biological and pharmacological activities, including its potential as an anti-inflammatory and analgesic agent. Its unique structure and properties make it an interesting target for further investigation and development in the field of pharmaceutical science.

Upstream product

• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 
• 98548-90-4 methyl pyrrolidine-3-carboxylate 
• 501-53-1 benzyl chloroformate 
• 188846-99-3 (+/-)-3-cyanopyrrolidine-1-carboxylic acid benzyl ester 
• 198959-37-4 pyrrolidine-3-carboxylic acid methyl ester hydrochloride 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 188527-21-1 1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 912444-74-7 1-benzyl 3-methyl 3-methylpyrrolidine-1,3-dicarboxylate 
• 188527-21-1 1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 
• 72088-42-7 C₈H₁₅NO 
• 912444-75-8 1-((benzyloxy)carbonyl)-3-methylpyrrolidine-3-carboxylic acid 

Relevant articles and documents

Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer

In this work, two series of cyclic amine-containing benzimidazole carboxamide derivatives were designed and synthesized as potent anticancer agents. PARP1/2 inhibitory activity assays indicated that most of the compounds showed significant activity. The in vitro antiproliferative activity of these compounds was investigated against four human cancer cell lines (MDA-MB-436, MDA-MB-231, MCF-7 and CAPAN-1), and several compounds exhibited strong cytotoxicity to tumor cells. Among them, 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide (17d) was found to be effective PARP1/2 inhibitors (IC50 = 4.30 and 1.58 nM, respectively). In addition, 17d possessed obvious selective antineoplastic activity and noteworthy microsomal metabolic stability. What's more, further studies revealed that 17d was endowed with an excellent ADME profile. These combined results indicated that 17d could be a promising candidate for the treatment of cancer.

1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.

With antifungal activity of the wicked zuozuo apperception compound and its preparation method and application (by machine translation)

The invention discloses an oxazole compound with anti-fungal activity, a preparation method of the oxazole compound and an application of the oxazole compound to tobacco powdery mildew original fungi or cotton anthracnose original fungi prevention, and belongs to the technical field of organic synthesis. The technical scheme mainly includes that the oxazole compound with the anti-fungal activity is provided with a structure shown in the instruction, R1 refers to propiono, isopropyl, acetyl, ethyl or methyl, and R2 refers to dimethylamino or methylamine. Five oxazole compounds with the anti-fungal activity are synthesized by the novel method, the preparation process is simple in technology and easy to control, target product yield is high, repeatability is fine, and the five prepared oxazole compounds with the anti-fungal activity have a certain prevention function for tobacco powdery mildew original fungi or cotton anthracnose original fungi.