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98548-90-4

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98548-90-4 Usage

Description

Methyl 3-pyrrolidinecarboxylate, with the molecular formula C7H11NO2, is a versatile ester derivative of pyrrolidinecarboxylic acid. It is a clear, colorless liquid with a faint odor, often utilized as a building block in organic synthesis and pharmaceutical research. Its low toxicity and mild effects on skin and eyes make it a popular choice for various industrial applications.

Uses

Used in Pharmaceutical Research:
Methyl 3-pyrrolidinecarboxylate is used as a versatile intermediate for the production of various pharmaceuticals. Its unique chemical structure allows it to be easily modified and incorporated into a wide range of drug molecules, making it a valuable asset in the development of new medications.
Used in Organic Synthesis:
As a building block in organic synthesis, Methyl 3-pyrrolidinecarboxylate is used to create a variety of chemical compounds. Its reactivity and functional groups enable it to participate in numerous chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Agricultural Chemicals:
Methyl 3-pyrrolidinecarboxylate is used as an intermediate in the production of agricultural chemicals. Its ability to be modified and incorporated into various chemical structures makes it a valuable component in the development of effective and safe agrochemicals.
Used as a Solvent in Chemical Reactions:
Due to its solubility properties and low toxicity, Methyl 3-pyrrolidinecarboxylate is commonly used as a solvent in chemical reactions. Its ability to dissolve a wide range of substances and facilitate reaction processes makes it a popular choice for various industrial applications.
Used in Fine Chemicals Production:
Methyl 3-pyrrolidinecarboxylate is used as an intermediate for the production of various fine chemicals. Its versatility and reactivity make it a valuable component in the synthesis of specialty chemicals used in industries such as fragrances, dyes, and coatings.

Check Digit Verification of cas no

The CAS Registry Mumber 98548-90-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,5,4 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98548-90:
(7*9)+(6*8)+(5*5)+(4*4)+(3*8)+(2*9)+(1*0)=194
194 % 10 = 4
So 98548-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2/c1-9-6(8)5-2-3-7-4-5/h5,7H,2-4H2,1H3

98548-90-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl pyrrolidine-3-carboxylate

1.2 Other means of identification

Product number -
Other names methyl pyrrolidine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98548-90-4 SDS

98548-90-4Relevant articles and documents

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease

Ning, Xiang-Li,Li, Yu-Zhi,Huo, Cui,Deng, Ji,Gao, Cheng,Zhu, Kai-Rong,Wang, Miao,Wu, Yu-Xiang,Yu, Jun-Lin,Ren, Ya-Li,Luo, Zong-Yuan,Li, Gen,Chen, Yang,Wang, Si-Yao,Peng, Cheng,Yang, Ling-Ling,Wang, Zhou-Yu,Wu, Yong,Qian, Shan,Li, Guo-Bo

supporting information, p. 8303 - 8332 (2021/06/30)

Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan 2,3-dioxygenase (hTDO) have been closely linked to the pathogenesis of Parkinson’s disease (PD); nevertheless, development of dual hIDO1 and hTDO inhibitors to evaluate their potential efficacy against PD is still lacking. Here, we report biochemical, biophysical, and computational analyses revealing that 1H-indazole-4-amines inhibit both hIDO1 and hTDO by a mechanism involving direct coordination with the heme ferrous and ferric states. Crystal structure-guided optimization led to23, which manifested IC50values of 0.64 and 0.04 μM to hIDO1 and hTDO, respectively, and had good pharmacokinetic properties and brain penetration in mice.23showed efficacy against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse motor coordination deficits, comparable to Madopar, an anti-PD medicine. Further studies revealed that different from Madopar,23likely has specific anti-PD mechanisms involving lowering IDO1 expression, alleviating dopaminergic neurodegeneration, reducing inflammatory cytokines and quinolinic acid in mouse brain, and increasing kynurenic acid in mouse blood.

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Hermant, Paul,Bosc, Damien,Piveteau, Catherine,Gealageas, Ronan,Lam, Baovy,Ronco, Cyril,Roignant, Matthieu,Tolojanahary, Hasina,Jean, Ludovic,Renard, Pierre-Yves,Lemdani, Mohamed,Bourotte, Marilyne,Herledan, Adrien,Bedart, Corentin,Biela, Alexandre,Leroux, Florence,Deprez, Benoit,Deprez-Poulain, Rebecca

, p. 9067 - 9089 (2017/11/14)

Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, though they may be very potent compounds in vitro. We designed a 57-member library of hydroxamic acids to explore the structure-plasma stability relationships in these series and to identify which enzyme(s) and which pharmacophores are critical for plasma stability. Arylesterases and carboxylesterases were identified as the main metabolic enzymes for hydroxamic acids. Finally, we suggest structural features to be introduced or removed to improve stability. This work thus provides the first medicinal chemistry toolbox (experimental procedures and structural guidance) to assess and control the plasma stability of hydroxamic acids and realize their full potential as in vivo pharmacological probes and therapeutic agents. This study is particularly relevant to preclinical development as it allows obtaining compounds equally stable in human and rodent models.

Novel phosphorus radical-based routes to horsfiline

Murphy, John A.,Tripoli, Regis,Khan, Tanweer A.,Mali, Umesh W.

, p. 3287 - 3289 (2007/10/03)

(Chemical Equation Presented) Radicals derived from the phosphorus reagents, ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO), are used in two related approaches to synthesis of the alkaloid horsfiline (1). In particular, DEPO proves

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