188918-50-5

Upstream product

• 188918-44-7 tert-butyl [(1R,3S)-3-acetyl-2,2-dimethylcyclobutyl]carbamate 
• 22571-78-4 (+)-cis-pinononoic acid 
• 1261253-73-9 (1S,3R)-benzyl 3-acetyl-2,2-dimethylcyclobutanecarboxylate 
• 1261253-74-0 (1S,3R)-benzyl 3-acetamido-2,2-dimethylcyclobutanecarboxylate 
• 136780-45-5 methyl (1S,3R)-3-acetyl-2,2-dimethylcyclobutanecarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 288848-24-8 (1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid 
• 80-57-9 (-)-Verbenone 
• 308287-83-4 (1S,3R)-(+)-3-(2-Acetamido)-2,2-dimethylcyclobutanecarboxylic acid 

Downstream Products

• 1261253-75-1 (1S,3R)-benzyl 3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylate 
• 1261253-61-5 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid 
• 1261253-65-9 (1R,3S)-1-benzyl 3-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylcyclobutane-1,3-dicarboxylate 
• 1261254-61-8 (1S,3R)-benzyl 3-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxamido)-2,2-dimethylcyclobutanecarboxylate 
• 1261253-77-3 (1S,3R)-benzyl 3-amino-2,2-dimethylcyclobutanecarboxylate trifluoroacetate 
• 1261252-77-0 (1S,3R)-benzyl 3-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-acetoxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxamido)-2,2-dimethylcyclobutanecarboxylate 
• 1313358-34-7 methyl (S)-1-(2-benzyl-2-((2S,3S)-3-((1S,3R)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 
• 1313358-27-8 methyl (S)-1-(2-((2S,3S)-3-((1S,3R)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 
• 1313358-37-0 methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-3-((1S,3R)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 
• 1313358-42-7 methyl (S)-1-(2-((2S,3S)-3-((1S,3R)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate 
• 527751-18-4 (1S,3R)-3-amino-2,2-dimethylcyclobutan-1-carboxylic acid 

Relevant academic research and scientific papers

Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations

Optically active samples of the N-protected 1,3-cyclobutane amino acids 1 and 2 were prepared from α-pinene. The synthesis of 1 is enantiodivergent insofar as both optical antipodes of the product can be prepared from the same α-pinene enantiomer. Single crystal X-ray diffraction studies of derivatives of 1 reveal these compounds can have extended conformations.

1,3,4-OXADIAZOLONE COMPOUND AND MEDICINE

The purpose of the present invention is to provide a compound having PIM inhibitory activity. Examples of the present invention include 1,3,4-oxadiazolone compounds represented by the following formula [1], and pharmaceutically acceptable salts, and solvates thereof. The compounds of the present invention have PIM inhibitory activity. In addition, since the compounds of the present invention have PIM inhibitory activity, the compounds of the present invention are useful as therapeutic agents for systemic lupus erythematosus, lupus nephritis, etc.

LUPEOL-TYPE TRITERPENE DERIVATIVES AS ANTIVIRALS

The invention relates to novel lupeol-type triterpene derivatives and related compounds, and pharmaceutical compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.

NOVEL AZA-PEPTIDES CONTAINING 2,2-DISUBSTITUTED CYCLOBUTYL AND/OR SUBSTITUTED ALKOXY BENZYL DERIVATIVES AS ANTIVIRALS

The present invention relates to novel aza-peptides containing 2,2-disubstituted 5 cyclobutyl and/or substituted alkoxy benzyl derivatives of formula (I) and compositions for inhibiting Human Immunodeficiency Virus (HIV) and process for making the compounds.