188936-07-4Relevant articles and documents
Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide
Nagao, Yoshihiro,Hisanaga, Tatsunari,Utsumi, Takahiro,Egami, Hiromichi,Kawato, Yuji,Hamashima, Yoshitaka
, p. 7290 - 7295 (2018/07/15)
We describe a concise enantioselective synthesis of the HIV-protease inhibitor nelfinavir (1) via a new route in which the key step is construction of the central optically active 1,2-amino alcohol framework via asymmetric bromocyclization of bisallylic amide with N-bromosuccinimide in the presence of a catalytic amount of (S)-BINAP or (S)-BINAP monoxide. The remaining alkene and bromo functionalities were used to install the requisite thioether and chiral perhydroisoquinoline units, respectively.
Process for producing amide derivatives and intermediates therefor
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, (2008/06/13)
PCT No. PCT/JP96/02756 Sec. 371 Date Apr. 14, 1998 Sec. 102(e) Date Apr. 14, 1998 PCT Filed Sep. 24, 1996 PCT Pub. No. WO97/11937 PCT Pub. Date Apr. 3, 1997A method for producing an amide derivative of the formula [XV] wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.
A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-l,3-dioxepan-6-ylammonium Acetate
Inaba, Takashi,Birchler, Angela G.,Yamada, Yasuki,Sagawa, Shoichi,Yokota, Katsuyuki,Ando, Koji,Uchida, Itsuo
, p. 7582 - 7583 (2007/10/03)
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