167678-46-8

Basic information

• Product Name: 3-ACETOXY-2-METHYLBENZOYL CHLORIDE
• Synonyms: Benzoyl chloride, 3-(acetyloxy)-2-methyl- (9CI);3-Acetoxy-2-methylbenzoylchloride (AMBC);2-METHYL-3-ACETOXYBENZOYLCHLORIDE;2-methyl-3-acetoxybenzoic chloride(3-acetoxy-2-methylbenzoic chloride);(1-[6-(Dimethylamino)-2-naphthalenyl]);2-Methyl-3-Acetoxybenzoic Chloride(3-Acetoxy-2-Methylbenzoic Ch;3-(Chlorocarbonyl)-2-Methylphenyl Acetate;Acetic Acid 3-Chlorocarbonyl-2-Methylphenyl Ester
• CAS NO: 167678-46-8
• Molecular Formula: C₁₀H₉ClO₃
• Molecular Weight: 212.63
• EINECS: 433-690-0
• Product Categories: ACIDHALIDE;Aromatics Compounds;Aromatics;Inhibitors
• Mol File: 167678-46-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 31-35°C
• Boiling Point: 148°C/11mmHg(lit.)
• Flash Point: 123.6 °C
• Appearance: light yellow oil
• Density: 1,25 g/cm3
• Vapor Pressure: 0.00151mmHg at 25°C
• Refractive Index: 1.532
• Solubility: Chloroform, Dichloromethane
• Sensitive: Moisture Sensitive
• BRN: 8054543
• CAS DataBase Reference: 3-ACETOXY-2-METHYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETOXY-2-METHYLBENZOYL CHLORIDE(167678-46-8)
• EPA Substance Registry System: 3-ACETOXY-2-METHYLBENZOYL CHLORIDE(167678-46-8)

Safety Data

• Statements: 34-43-35
• Safety Statements: 26-36/37/39-45-7/8
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 167678-46-8(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

An intermediate in the preparation of small-sized HIV protease inhibitors.

InChI:InChI=1/C10H9ClO3/c1-6-8(10(11)13)4-3-5-9(6)14-7(2)12/h3-5H,1-2H3

Upstream product

• 168899-58-9 3-acetoxy-2-methylbenzoic acid 

Downstream Products

• 854052-94-1 acetic acid 2-methyl-3-(methylphenylcarbamoyl)phenyl ester 
• 1428858-44-9 4-butyl-2-methyl-3-(quinolin-8-ylcarbamoyl)phenyl acetate 
• 245414-50-0 Acetic acid 3-[(1S,2R)-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propylcarbamoyl]-2-methyl-phenyl ester 
• 245414-50-0 Acetic acid 3-[(1R,2S)-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propylcarbamoyl]-2-methyl-phenyl ester 
• 245414-50-0 Acetic acid 3-[(1S,2S)-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propylcarbamoyl]-2-methyl-phenyl ester 

Relevant articles and documents

Two new benzamides: Synthesis, spectroscopic characterization, X-ray diffraction, and electronic structure analyses

This work includes the syntheses, molecular and electronic structure analyses of two novel secondary amide compounds 3-acetoxy-2-methyl-N-(2-methoxyphenyl)benzamide, 1 and 3-acetoxy-2-methyl-N-(3-methylphenyl)benzamide, 2. The title compounds were charact

Synthesis, characterization, antioxidant, and antibacterial activities of new 2,3-dimethoxy and 3-acetoxy-2-methyl benzamides

Abstract: We performed a series of novel benzamide compounds which were synthesized starting from 2,3-dimethoxybenzoic acid or 3-acetoxy-2-methylbenzoic acid and amine derivatives. All the obtained products were purified, and the analysis of these product

Rhodium-Catalyzed Alkenylation of C-H Bonds in Aromatic Amides with Alkynes

The rhodium-catalyzed alkenylation of C-H bonds of aromatic amides with alkynes is reported. A variety of functional groups, including OMe, OAc, Br, Cl, and even NO2, are applicable to this reaction to give the corresponding hydroarylation prod