188947-24-2Relevant articles and documents
Peptidyl α-keto thiazole as potent thrombin inhibitors
Akiyama, Yoshihisa,Tsutsumi, Seiji,Hatsushiba, Emiko,Ohuchi, Shoukichi,Okonogi, Tsuneo
, p. 533 - 538 (1997)
We report the synthesis and evaluation of α-keto thiazole derivatives such as D-Phe-Pro-Arg-thiazole 9 as a novel type of thrombin inhibitor. Tripeptidyl α-keto thiazole 9 exhibited the inhibitory activity of thrombin at nanomolar levels and showed a more