Bioorganic and Medicinal Chemistry Letters p. 533 - 538 (1997)
Update date:2022-08-05
Topics:
Akiyama, Yoshihisa
Tsutsumi, Seiji
Hatsushiba, Emiko
Ohuchi, Shoukichi
Okonogi, Tsuneo
We report the synthesis and evaluation of α-keto thiazole derivatives such as D-Phe-Pro-Arg-thiazole 9 as a novel type of thrombin inhibitor. Tripeptidyl α-keto thiazole 9 exhibited the inhibitory activity of thrombin at nanomolar levels and showed a more
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