Peptidyl α-keto thiazole as potent thrombin inhibitors

DOI: 10.1016/S0960-894X(97)00057-7

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Bioorganic and Medicinal Chemistry Letters p. 533 - 538 (1997)

Update date:2022-08-05

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Authors:

Akiyama, Yoshihisa

Tsutsumi, Seiji

Hatsushiba, Emiko

Ohuchi, Shoukichi

Okonogi, Tsuneo

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Article abstract of DOI:10.1016/S0960-894X(97)00057-7

We report the synthesis and evaluation of α-keto thiazole derivatives such as D-Phe-Pro-Arg-thiazole 9 as a novel type of thrombin inhibitor. Tripeptidyl α-keto thiazole 9 exhibited the inhibitory activity of thrombin at nanomolar levels and showed a more

Full text of DOI:10.1016/S0960-894X(97)00057-7

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