18895-10-8

Basic information

• Product Name: 4-BROMO-3-CYANOTHIOPHENE
• Synonyms: 4-BROMO-3-CYANOTHIOPHENE;4-BROMOTHIOPHENE-3-CARBONITRILE;3-Bromo-4-cyanothiophene;3-Bromothiophene-4-carbonitrile;4-Bromthiophene-3-carbonitrile;4-Bromothiophene-3-carbonitrile 97%
• CAS NO: 18895-10-8
• Molecular Formula: C₅H₂BrNS
• Molecular Weight: 188.04508
• Product Categories: Cyano;Organohalides;Thiophene
• Mol File: 18895-10-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 289.1 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: /
• Density: 1.82 g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-BROMO-3-CYANOTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-CYANOTHIOPHENE(18895-10-8)
• EPA Substance Registry System: 4-BROMO-3-CYANOTHIOPHENE(18895-10-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 18895-10-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-cyanothiophene is a chemical compound with the molecular formula C6H3BrNS, consisting of a bromine atom, a cyano group, and a thiophene ring. It is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various organic compounds. Due to its unique chemical structure, 4-bromo-3-cyanothiophene has desirable properties for applications in material science, such as in the development of organic semiconductors, liquid crystals, and optoelectronic devices. Its versatility and reactivity make it a valuable intermediate in the production of various functional materials, making it an important molecule for research and industrial processes.

InChI:InChI=1/C5H2BrNS/c6-5-3-8-2-4(5)1-7/h2-3H

Upstream product

• 3141-26-2 3,4-dibromothiophene 
• 557-21-1 dicyanozinc 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 
• 18791-78-1 4-bromothiophene-3-carboxaldehyde 
• 544-92-3 copper(I) cyanide 
• 18791-95-2 4-bromothiophene-3-carbaldehyde oxime 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 100245-61-2 4-bromothiophene-3-carboxamide 

Downstream Products

• 1150566-11-2 t-butyl-4-(4-cyanothiophen-3-yl)phenylcarbamate 
• 1641-09-4 3-thiophenecarbonitrile 
• 100245-61-2 4-bromothiophene-3-carboxamide 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

HCV INHIBITORS

The present invention provides HCV polymerase inhibiting compounds having the formula (I) where R1is cyclobutyl-N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-

Palladium-Catalyzed Cyanation Reactions of Thiophene Halides

The described method provides an efficient cyanation reaction of thiophene halides using tris(dibenzylidene-acetone)dipalladium(0), 1,1′-bis- (diphenylphosphino)ferrocene) and zinc powder as the catalyst system and Zn(CN)2 as the cyanide source