188973-49-1

Basic information

• Product Name: 1-Hexanone, 6-bromo-1-(4-methylphenyl)-
• CAS NO: 188973-49-1
• Molecular Formula: C13H17BrO
• Molecular Weight: 269.181
• Mol File: 188973-49-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Hexanone, 6-bromo-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hexanone, 6-bromo-1-(4-methylphenyl)-(188973-49-1)
• EPA Substance Registry System: 1-Hexanone, 6-bromo-1-(4-methylphenyl)-(188973-49-1)

Safety Data

• Hazardous Substances Data: 188973-49-1(Hazardous Substances Data)

Upstream product

• 4224-70-8 6-bromohexanoic acid 
• 66117-64-4 di(p-tolyl)borinic acid 
• 1821-24-5 1-(p-methylphenyl)cyclohexanol 
• 624-31-7 4-tolyl iodide 
• 108-94-1 cyclohexanone 
• 22809-37-6 6-bromohexanoyl chloride 
• 108-88-3 toluene 

Downstream Products

• 1057648-58-4 6-(4'-(hydroxy(diphenyl)methyl)piperidin-1-yl)-1-(4-methylphenyl)hexan-1-one 
• 79654-72-1 6-(4-methylphenyl)-1-bromohexane 

Relevant articles and documents

Electrophotochemical Ring-Opening Bromination oftert-Cycloalkanols

An electrophotochemical ring-opening bromination of unstrainedtert-cycloalkanols has been developed. This electrophotochemical method enables the oxidative transformation of cycloalkanols with 5- to 7-membered rings into synthetically useful ω-bromoketones without the use of chemical oxidants or transition-metal catalysts. Alkoxy radical species would be key intermediates in the present transformation, which generate through homolysis of the O-Br bond in hypobromite intermediates under visible light irradiation.

Palladium-Catalyzed Room-Temperature Acylative Suzuki Coupling of High-Order Aryl Borons with Carboxylic Acids

This note describes a dimethyl dicarbonate-assisted, Pd(OAc)2/PPh3-catalyzed acylative Suzuki coupling of carboxylic acids with diarylborinic acids or tetraarylboronates for practical and efficient synthesis of sterically undemanding aryl ketones at room temperature. More than just cost-effective alternatives to aryl boronic acids, diarylborinic acids and tetraarylboronates displayed higher reactivity in the acylative Suzuki coupling. A variety of alkyl aryl ketones, including those bearing a hydroxy, bromo, or carbonyl group, could be readily obtained in modest to excellent yields.

Synthesis of neuroprotective cyclopentenone prostaglandin analogs: Suppression of manganese-induced apoptosis of PC12 cells

The synthesis and evaluation for anti- and proapoptotic properties of cyclopentenone prostaglandin analogs are described. Novel J-type analogs of NEPP11 with a cross-conjugated cyclopentadienone moiety and a lipophilic ω-side chain suppressed manganese io