189019-32-7

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 100-42-5 styrene 
• 189019-31-6 4-benzyltetrahydro-2H-pyran-4-ol 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 124620-30-0 1-phenethyl-cyclohexanol 
• 189019-34-9 N-(4-Phenethyltetrahydropyran-4-yl)-formamide 

Relevant academic research and scientific papers

Catalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds

Generation of a ketyl radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described. The method is applicable to both aliphatic ketones and aldehydes to afford the corresponding tertiary and secondary alcohols in continuous flow and batch. Preliminary mechanistic investigation suggests the catalytic formation of a ketyl radical intermediate.

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.