124620-30-0

Basic information

• Product Name: 1-Phenethylcyclohexanol
• Synonyms: 1-(2-Phenylethyl)cyclohexanol;1-Phenethylcyclohexanol
• CAS NO: 124620-30-0
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.31
• Mol File: 124620-30-0.mol

Chemical Properties

• Melting Point: 55-56 °C
• Boiling Point: 165 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.020±0.06 g/cm3(Predicted)
• PKA: 15.17±0.20(Predicted)
• CAS DataBase Reference: 1-Phenethylcyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenethylcyclohexanol(124620-30-0)
• EPA Substance Registry System: 1-Phenethylcyclohexanol(124620-30-0)

Safety Data

• Hazardous Substances Data: 124620-30-0(Hazardous Substances Data)

Upstream product

• 3277-89-2 phenethylmagnesium bromide 
• 108-94-1 cyclohexanone 
• 90878-19-6 phenethylmagnesium chloride 
• 2021-28-5 ethyl dihydrocinnamate 
• 23708-48-7 pentamethylenebis(magnesium bromide) 
• 17376-04-4 2-phenethyl iodide 
• 622-24-2 2-phenylethyl chloride 
• 103-63-9 1-phenyl-2-bromoethane 
• 100-42-5 styrene 
• 189019-32-7 4-phenethyltetrahydro-2H-pyran-4-ol 
• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 

Downstream Products

• 15232-90-3 (2-(cyclohex-1-en-1-yl)ethyl)benzene 
• 19634-93-6 cis-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-one 
• 50765-07-6 1-(phenethyl)cyclohexylamine hydrochloride 

Relevant articles and documents

Samarium-based Grignard-type addition of organohalides to carbonyl compounds under catalysis of CuI

Grignard-type additions were readily achieved under the mediation of CuI (10 mol%) and samarium (2 equiv.) by employing various organohalides,e.g.benzyl, aryl, heterocyclic and aliphatic halides (Cl, Br or I), and diverse carbonyl compounds (e.g.carbonic esters, carboxylic esters, acid anhydrides, acyl chlorides, ketones, aldehydes, propylene epoxides and formamides) to afford alcohols, ketones and aldehydes, respectively, with high efficiency and chemoselectivity, in which the organosamarium intermediate might be involved.

Strecker-type reaction of nitrones using cyanohydrin

Strecker-type reaction of nitrones using acetone cyanohydrin as a cyanide source was developed. By treating nitrones with acetone cyanohydrin in the presence of n-BuMgCl, transcyanation from the cyanohydrin to the nitrones smoothly proceeded in THF at 35 °C. The amount of n-BuMgCl could be reduced to 0.2 equiv to give the corresponding α-cyanohydroxylamines in up to 98% yields.

Substituted cycloalkyl derivatives for the treatment of respiratory diseases

N-(Phenyl-substituted cycloalkyl or cycloalkylmethyl)-phenylethanolamine derivatives (I) (including benzo-heterocyclic analogs) are new. Also new are cyclopropylamine or cyclopropylmethylamine derivative intermediates (II). Phenylethanolamine derivatives of formula (I) (including optical isomers, enantiomer mixtures and racemates) and their salts, solvates and hydrates are new. n : 0 or 1; m : 1-4; X : direct bond, 2-6C alkenylene, -O-Q-, -NH-Q-, -S-Q- or -Q-; Q : 1-6C alkylene; R 1>H; and R 3>hydroxyalkyl or halo; or R 1> + R 2>OCH 2CONH, CH 2CH 2CONH, CH=CHCONH, NHCH 2CONH, SCH 2CONH, OCONH, SCONH, NHCONH or OCH 2SO 2NH (all optionally substituted (os) by 1 or 2 of alkyl, OH or halo); R 3>, R 4>H, OH, halo, 1-6C alkyl, 1-6C haloalkyl, 1-6C hydroxyalkyl, NH 2 or mono- or dialkylamino; R 5> - R 8>H, OR 9>, halo, 1-6C alkyl, 1-6C haloalkyl, 1-6C hydroxyalkyl, 3-6C cycloalkyl, 3-6C hydroxycycloalkyl, CN, NO 2, COR 9>, COOR 9>, CONR 10>R 11>, NR 10>R 11>, NR 10>COR 9>, NR 10>SO 2R 12>, SR 12>, SOR 12>, SO 2R 12>, SO 2NR 10>R 11> or halo; or two vicinal groups R 6> - R 8> together= 2-6C alkylene, 2-6C alkenylene or O-Q-O (all os by 1 or 2 of alkyl, alkoxy, OH or halo); R 9> - R 11>H, alkyl, aryl or arylalkyl; R 12>alkyl, aryl or arylalkyl; unless specified otherwise alkyl moieties have 1-4C and aryl moieties 6-10C. An independent claim is included for cycloalkylamine or cycloalkylalkylamine derivative intermediates of formula (II) as new compounds, provided that m= 1. [Image] [Image] ACTIVITY : Antiinflammatory; antiasthmatic; antiallergic; virucide; antibacterial; fungicide; protozoacide; anthelmintic; cardiant; dermatological; immunosuppressive; tocolytic; antiarrhythmic; vasotropic; antipruritic. MECHANISM OF ACTION : beta -Mimetic.

Utility of neodymium diiodide as a reductant in ketone coupling reactions

Matrix presented The viability of Ndl2 as a one-electron reducing agent in organic synthesis has been examined by studying coupling reactions between alkyl chlorides and ketones and aldehydes.

DTBB-Catalysed dilithiation of styrene and its methyl-derivatives: Introduction of two electrophilic reagents

The reaction of styrene and some methyl-substituted styrenes 1 with lithium and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB) in the presence of several electrophiles [Me3SiCl, Me2CO, Et2CO, (CH2)5CO, Pr2CO], in THF, at temperatures ranging from -78 to 0°C, gave, after hydrolysis, products 2 resulting from addition of lithium to the olefinic double bond and successive trapping with the electrophilic reagent. When a carbonyl compound was used as electrophile, mixtures of the monoaddition-reduction compounds 3 and 4 were obtained as by-products, which could be easily separated from the diaddition products 2.

Samarium-mediated Barbier reaction of carbonyl compounds

Samarium metal in the presence of catalytic amounts of iodine was found to be effective for the Barbier reaction of carbonyl compounds.

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.