58822-02-9

Upstream product

• 7678-84-4 3-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one 
• 213970-42-4 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol 
• 77-78-1 dimethyl sulfate 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 124555-63-1 4-methoxy-2-methoxymethoxy benzaldehyde 
• 126809-68-5 2-(methoxymethoxy)-4-methoxybenzyl alcohol 
• 152955-15-2 4-methoxy-2-O-methoxymethylbenzyl bromide 
• 213970-38-8 2-(2,4-dimethoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol 
• 213970-33-3 methyl 2-(2,4-dimethoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)propanoate 
• 1855-30-7 1-(2,4-dihydroxyphenyl)-2-(2,4-dimethoxyphenyl)ethanone 
• 70779-11-2 1-(2-hydroxy-4 methoxyphenyl)-2-(2,4-dimethoxyphenyl)ethanone 
• 1891-11-8 (2,4-dimethoxyphenyl)acetonitrile 
• 108-46-3 recorcinol 
• 1029608-25-0 C₁₉H₂₂O₅ 

Relevant academic research and scientific papers

o-Quinone methide based approach to isoflavans: application to the total syntheses of equol, 3′-hydroxyequol and vestitol

A concise strategy is developed for the synthesis of isoflavans employing a Diels-Alder reaction between o-quinone methides and aryl-substituted enol ethers followed by reductive cleavage of the acetal group. The method is extended towards the total syntheses of equol, 3′-hydroxyequol and vestitol.

The direct synthesis of isoflavans VIA α-alkylation of phenylacetates

Deprotonation of oxygenated phenylacetates and quenching of the enolates with oxygenated benzylic electrophiles, afforded 2,3-diarylpropanoates which served as precursors to the isoflavans following consecutive reduction and cyclization steps.