189102-63-4

Upstream product

• 66774-80-9 (S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate 
• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 189102-19-0 (R)-1-((1S,3aR,4S,7aR)-7a-Methyl-4-triethylsilanyloxy-octahydro-inden-1-yl)-ethanol 
• 189102-18-9 des-A,B-8β-[(triethylsilyl)oxy]-22-(p-toluenesulfonyloxy)-23,24-dinorcholane 
• 189102-59-8 ((1S,3aR,4S,7aR)-1-{(R)-1-[2-((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethoxy]-ethyl}-7a-methyl-octahydro-inden-4-yloxy)-triethyl-silane 
• 189102-22-5 (1S,3aR,7aR)-1-{(R)-1-[2-((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethoxy]-ethyl}-7a-methyl-octahydro-inden-4-one 
• 189102-20-3 Toluene-4-sulfonic acid 2-((S)-5,5-diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester 
• 189102-21-4 (1S,3aR,4S,7aS)-1-{(R)-1-[2-((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethoxy]-ethyl}-7a-methyl-octahydro-inden-4-ol 
• 186372-30-5 (1R,3aR,4S,7aR)-octahydro-1-[(1’S)-1’-methyl-2’-oxo-ethanyl]-7a-methyl-4-triethylsilyloxy-1H-indene 
• 189102-57-6 des-A,B-8β-[(triethylsilyl)oxy]-pregnane-20-one 
• 50-14-6 Calciferol 

Relevant academic research and scientific papers

Antiproliferative hybrid analogs of the hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

The combination of 10-12 kbar pressure plus Lewis acidic zinc dichloride promotes highly regioselective and stereoselective Diels-Alder cycloaddition between 3-bromo-2-pyrone, prepared in a new way, and unactivated terminal alkene 4-(tert-butyldimethylsiloxy)-1-butene. The conjugate base of A-ring allylic phosphine oxide 20 adds chemospecifically to the C-8 keto group of some C-8,C-24-diketones to form directly metabolically resistant 24-oxo analogs of 1α,25-dihydroxyvitamin D3 (calcitriol). Several of these new hybrid analogs are as efficacious in vitro as calcitriol at inhibiting growth of murine keratinocytes even at physiologically relevant 10-100 nanomolar concentrations.