18912-81-7

Basic information

• Product Name: C5E2
• Synonyms: PENTYLDIGLYCOL;N-PENTYLDIOXYETHYLENE;C5E2;DIETHYLENEGLYCOLMONOPENTYL ETHER;2-(2-PENTYLOXYETHOXY)ETHANOL;Ethanol, 2-2-(pentyloxy)ethoxy-;2-(2-Pentyloxyethoxy)ethanol, C5E2, Pentyldiglycol;1,4,7-Trioxadodecane
• CAS NO: 18912-81-7
• Molecular Formula: C₉H₂₀O₃
• Molecular Weight: 176.25
• Mol File: 18912-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 255°C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 0.942 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00254mmHg at 25°C
• Refractive Index: n20/D 1.435
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C5E2(CAS DataBase Reference)
• NIST Chemistry Reference: C5E2(18912-81-7)
• EPA Substance Registry System: C5E2(18912-81-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• Hazardous Substances Data: 18912-81-7(Hazardous Substances Data)

Usage

Uses

Diethylene Glycol Monopentyl Ether is a compound that has been considered as a propellant-solution surfactant for the delivery of peptide-based pharmaceuticals to the respiratory tract.

InChI:InChI=1/C9H20O3/c1-2-3-4-6-11-8-9-12-7-5-10/h10H,2-9H2,1H3

Upstream product

• 75-21-8 oxirane 
• 6196-58-3 2-(pentyloxy)ethanol 
• 110-53-2 1-Bromopentane 
• 111-46-6 diethylene glycol 
• 71-41-0 pentan-1-ol 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDIN DERIVATIVES AS INHIBITORS OF INFLUENZA VIRUS REPLICATION

Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.