189145-39-9 Usage
Chemical properties
The compound is likely to have various chemical properties, including reactivity with other molecules and potential for forming complexes.
Biological properties
The compound may have potential biological properties, such as antioxidant, antibacterial, or antiviral effects.
Applications
The specific functions and applications of this compound would need to be determined through further research and testing.
Stability
The stability of the compound under different conditions, such as temperature, pH, and exposure to light, would need to be investigated.
Solubility
The compound's solubility in different solvents, such as water, organic solvents, or buffer solutions, would need to be determined.
Toxicity
The potential toxicity of the compound, both in terms of acute and chronic exposure, would need to be assessed.
Synthesis
The methods and conditions for synthesizing the compound, including the starting materials, reaction conditions, and purification techniques, would need to be established.
Characterization
The compound's structure and properties would need to be confirmed through various analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and elemental analysis.
Purity
The purity of the compound, including the presence of any impurities or degradation products, would need to be assessed and controlled.
Check Digit Verification of cas no
The CAS Registry Mumber 189145-39-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,1,4 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 189145-39:
(8*1)+(7*8)+(6*9)+(5*1)+(4*4)+(3*5)+(2*3)+(1*9)=169
169 % 10 = 9
So 189145-39-9 is a valid CAS Registry Number.
189145-39-9Relevant articles and documents
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin
Franchetti, Palmarisa,Cappellacci, Loredana,Sheikha, Ghassan Abu,Jayaram, Hiremagalur N.,Gurudutt, Vivek V.,Sint, Thaw,Schneider, Bryan P.,Jones, William D.,Goldstein, Barry M.,Perra, Graziella,De Montis, Antonella,Loi, Anna Giulia,La Colla, Paolo,Grifantini, Mario
, p. 1731 - 1737 (1997)
The synthesis and biological activity of selenophenfurin (5-β-D- ribofuranosylselenophene-3-carboxamide, 1), the selenophene analogue of selenazofurin, are described. Glycosylation of ethyl selenophene-3- carboxylate (6) under stannic chloride-catalyzed conditions gave 2- and 5- glycosylated regioisomers, as a mixture of α- and β-anomers, and the β- 2,5-diglycosylated derivative. Deprotected ethyl 5-β-D- ribofuranosylselenophene-3-carboxylate (12β) was converted into selenophenfurin by ammonolysis. The structure of 12β was determined by 1H- and 13C-NMR, crystallographic, and computational studies. Selenophenfurin proved to be antiproliferative against a number of leukemia, lymphoma, and solid tumor cell lines at concentrations similar to those of selenazofurin but was more potent than the thiophene and thiazole analogues thiophenfurin and tiazofurin. Incubation of K562 cells with selenophenfurin resulted in inhibition of IMP dehydrogenase (IMPDH) (76%) and an increase in IMP pools (14.5-fold) with a concurrent decrease in GTP levels (58%). The results obtained confirm the hypothesis that the presence of heteroatoms such as S or Se in the heterocycle in position 2 with respect to the glycosidic bond is essential for both cytotoxicity and IMP dehydrogenase inhibitory activity in this type of C-nucleosides.
