Synthesis and cytotoxic activity of selenophenfurin, a new inhibitor of IMP dehydrogenase

Article abstract of DOI:10.1080/07328319708006129

The synthesis of 5-β-D-ribofuranosylselenophene-3-carboxamide (selenophenfurin) is reported. Selenophenfurin was found active as cytotoxic agent and as inosine monophosphate dehydrogenase inhibitor.

Full text of DOI:10.1080/07328319708006129

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Nucleosides and Nucleotides
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Synthesis and Cytotoxic Activity of
Selenophenfurin, a New Inhibitor of
IMP Dehydrogenase
L. Cappellacci a , P. Franchetti a , G. Abu Sheikha a , H. N.
Jayaram b , V. V. Gurudutt b , T. Sint b , B. P. Schneider b , B. M.
Goldstein c , G. Perra d , S. Poma d , P. La Colla d & M. Grifantini
a
a Dipartimento di Scienze Chimiche , Università di Camerino ,
62032, Camerino, Italy
b Laboratory for Experimental Oncology , Indiana University
School of Medicine , Indianapolis, Indiana, 46202, USA
c Department of Biophysics , University of Rochester Medical
Center , Rochester, New York, 14642, USA
d Dipartimento di Biologia Sperimentale , Università di Cagliari ,
09124, Cagliari, Italy
Published online: 16 Aug 2006.
To cite this article: L. Cappellacci , P. Franchetti , G. Abu Sheikha , H. N. Jayaram ,
V. V. Gurudutt , T. Sint , B. P. Schneider , B. M. Goldstein , G. Perra , S. Poma , P. La
Colla & M. Grifantini (1997) Synthesis and Cytotoxic Activity of Selenophenfurin, a New
Inhibitor of IMP Dehydrogenase, Nucleosides and Nucleotides, 16:7-9, 1045-1048, DOI:
10.1080/07328319708006129
To link to this article: http://dx.doi.org/10.1080/07328319708006129
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